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Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome

Abstract : Brugada syndrome and early repolarization syndrome are both classified as J-wave syndromes, with a similar mechanism of arrhythmogenesis and with the same basis for genesis of the characteristic electrocardiographic features. The Brugada syndrome is now considered a conduction disorder based on subtle structural abnormalities in the right ventricular outflow tract. Recent evidence suggests structural substrate in patients with the early repolarization syndrome as well. We propose a unifying mechanism based on these structural abnormalities explaining both arrhythmogenesis and the electrocardiographic changes. In addition, we speculate that, with increasing technical advances in imaging techniques and their spatial resolution, these syndromes will be reclassified as structural heart diseases or cardiomyopathies.
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https://hal.inria.fr/hal-03133273
Contributor : Mark Potse Connect in order to contact the contributor
Submitted on : Friday, February 5, 2021 - 7:44:58 PM
Last modification on : Saturday, December 4, 2021 - 3:44:01 AM
Long-term archiving on: : Friday, May 7, 2021 - 8:29:09 AM

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Bastiaan Boukens, Mark Potse, Ruben Coronel. Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome. International Journal of Molecular Sciences, MDPI, 2021, 22 (4), pp.1570. ⟨10.3390/ijms22041570⟩. ⟨hal-03133273⟩

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