Simulation of a detoxifying organ function: Focus on hemodynamics modeling and convection‐reaction numerical simulation in microcirculatory networks - Archive ouverte HAL Access content directly
Journal Articles International Journal for Numerical Methods in Biomedical Engineering Year : 2021

Simulation of a detoxifying organ function: Focus on hemodynamics modeling and convection‐reaction numerical simulation in microcirculatory networks

(1, 2) , (3, 2) , (3)
1
2
3

Abstract

When modeling a detoxifying organ function, an important component is the impact of flow on the metabolism of a compound of interest carried by the blood. We here study the effects of red blood cells (such as the Fahraeus-Lindqvist effect and plasma skimming) on blood flow in typical microcirculatory components such as tubes, bifurcations and entire networks, with particular emphasis on the liver as important representative of detoxifying organs. In one of the plasma skimming models, under certain conditions, oscillations between states are found and analyzed in a methodical study to identify their causes and influencing parameters. The flow solution obtained is then used to define the velocity at which a compound would be transported. A convection-reaction equation is studied to simulate the transport of a compound in blood and its uptake by the surrounding cells. Different types of signal sharpness have to be handled depending on the application to address different temporal compound concentration profiles. To permit executing the studied models numerically stable and accurate, we here extend existing transport schemes to handle converging bifurcations, and more generally multi-furcations. We study the accuracy of different numerical schemes as well as the effect of reactions and of the network itself on the bolus shape. Even though this study is guided by applications in liver micro-architecture, the proposed methodology is general and can readily be applied to other capillary network geometries, hence to other organs or to bioengineered network designs.
Fichier principal
Vignette du fichier
ijnmbeFinalHAL.pdf (19.31 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03135175 , version 1 (08-02-2021)

Identifiers

Cite

Noemie Boissier, Dirk Drasdo, Irene Vignon-Clementel. Simulation of a detoxifying organ function: Focus on hemodynamics modeling and convection‐reaction numerical simulation in microcirculatory networks. International Journal for Numerical Methods in Biomedical Engineering, 2021, 37 (2), ⟨10.1002/cnm.3422⟩. ⟨hal-03135175⟩
89 View
89 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More