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Forecast of the MMSE score up to 6 years ahead, with cross-cohort replications

Abstract : Most of the studies that focus on the Alzheimer’s disease (AD) prediction forecast a dementia label: cognitively normal, mild cognitive impairments or AD. However, these labels cannot always be compared across cohorts, they are not perfectly accurate and they describe the disease thanks to a limited number of stages (only 3) contrary to what is, in practice, a continuous progression. For these reasons, we predict the Mini-Mental State Examination (MMSE), a cognitive test whose scale presents 30 discrete values. Predicting this measure, assessed in multiple AD-related cohorts, allows better staging of the disease progression at the individual level, in particular in the ADNI, AIBL and PharmaCOG cohorts.
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https://hal.inria.fr/hal-03137878
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Submitted on : Wednesday, February 10, 2021 - 5:07:16 PM
Last modification on : Friday, January 21, 2022 - 3:17:12 AM
Long-term archiving on: : Tuesday, May 11, 2021 - 8:57:51 PM

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  • HAL Id : hal-03137878, version 1

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Etienne Maheux, Igor Koval, Damiano Archetti, Alberto Redolfi, Stanley Durrleman​. Forecast of the MMSE score up to 6 years ahead, with cross-cohort replications. CompAge 2020 - Computational approaches for ageing and age-related diseases, Sep 2020, Paris / Virtual, France. ⟨hal-03137878⟩

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