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Secure distribution of Factor Analysis of Mixed Data (FAMD) and its application to personalized medicine of transplanted patients

Sirine Sayadi 1, 2, 3, 4 Estelle Geffard 3, 4 Mario Südholt 1, 2 Nicolas Vince 3, 4 Pierre-Antoine Gourraud 3, 5, 4
1 STACK - Software Stack for Massively Geo-Distributed Infrastructures
Inria Rennes – Bretagne Atlantique , LS2N - Laboratoire des Sciences du Numérique de Nantes
2 IMT Atlantique - DAPI - Département Automatique, Productique et Informatique
3 Team 5 - U1064 Inserm - CRTI - Translational ImmunoGenetic in AutoImmunity and Transplantation
U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
4 UN - Université de Nantes
5 CHU Nantes - Centre hospitalier universitaire de Nantes
Abstract : Factor analysis of mixed data (FAMD) is an important statistical technique that not only enables the visualization of large data but also helps to select subgroups of relevant information for a given patient. While such analyses are well- known in the medical domain, they have to satisfy new data governance constraints if reference data is distributed, notably in the context of large consortia developing the coming generation of personalised medicine analyses. In this paper we motivate the use of distributed implementations for FAMD analyses in the context of the development of a personalised medicine application called KITAPP. We present a new distribution method for FAMD and evaluate its imple- mentation in a multi-site setting based on real data. Finally we study how individual reference data is used to substantiate decision making, while enforcing a high level of usage control and data privacy for patients.
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Conference papers
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https://hal.archives-ouvertes.fr/hal-03141653
Contributor : Sirine Sayadi <>
Submitted on : Monday, February 15, 2021 - 2:06:12 PM
Last modification on : Friday, March 5, 2021 - 11:20:05 AM

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  • HAL Id : hal-03141653, version 1

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EC-NANTES | UNAM | LS2N | IMT-ATLANTIQUE | UNIV-NANTES | CRTI | LS2N-STACK | CNRS | INRIA | INSTITUT-TELECOM

Citation

Sirine Sayadi, Estelle Geffard, Mario Südholt, Nicolas Vince, Pierre-Antoine Gourraud. Secure distribution of Factor Analysis of Mixed Data (FAMD) and its application to personalized medicine of transplanted patients. AINA 2021 : 35th International Conference on Advanced Information Networking and Applications, May 2021, Toronto, Canada. ⟨hal-03141653⟩

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