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Conference papers

Control of negative feedback loops in genetic networks

Ismail Belgacem 1 Jean-Luc Gouzé 2, 3 Roderick Edwards 1
2 BIOCORE - Biological control of artificial ecosystems
CRISAM - Inria Sophia Antipolis - Méditerranée , LOV - Laboratoire d'océanographie de Villefranche, INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
Abstract : The oscillator made of a negative loop of two genes is one of the most classical motifs of genetic networks. We give solutions to control such an oscillator by modifying the synthesis rates. Our models are given by piecewise affine systems, and the control is qualitative, taking only two values. Thus, the necessary measurements for implementing this control only depend on the fact that some gene is expressed or not. Our first goal is to obtain sustained oscillations. Then we study the control by a sliding mode for negative ODE loops in general, to suppress sustained or damped oscillations. Finally, we introduced a general idea for creating sustained oscillations in systems with damped oscillations following a particular cycle of domains.
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Submitted on : Wednesday, February 17, 2021 - 10:28:39 PM
Last modification on : Thursday, January 20, 2022 - 5:29:00 PM
Long-term archiving on: : Tuesday, May 18, 2021 - 7:53:54 PM


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  • HAL Id : hal-03144847, version 1


Ismail Belgacem, Jean-Luc Gouzé, Roderick Edwards. Control of negative feedback loops in genetic networks. CDC 2020 - 59th Conference on Decision and Control, Dec 2020, Jeju Island / Virtual, South Korea. ⟨hal-03144847⟩



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