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Journal Articles (Review Article) Current Opinion in Endocrine and Metabolic Research Year : 2021

Mathematical modeling of ovarian follicle development : A population dynamics viewpoint

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Abstract

Among endocrine organs, ovaries are unique because their function is supported by an ever-changing number of histological entities, the ovarian follicles, which are themselves subject to asynchronous development from their formation up to ovulation. Follicle development combines finely controlled processes of cell dynamics with original morphogenesis steps. Understanding the dynamics of follicle populations, on the whole ovary level, and the coupled dynamics of the oocyte and somatic cells, on the follicle level, is crucial to understand ovarian physiology and ovarian aging. Mathematical modeling studies combined with proper experimental approaches can be particularly helpful for gaining insight into follicle dynamics on different scales.

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hal-03146955 , version 1 (19-02-2021)

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Frédérique Clément, Danielle Monniaux. Mathematical modeling of ovarian follicle development : A population dynamics viewpoint. Current Opinion in Endocrine and Metabolic Research, 2021, 18, pp.54-61. ⟨10.1016/j.coemr.2021.02.003⟩. ⟨hal-03146955⟩
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