HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome

Abstract : We report a longitudinal analysis of the immune response associated with a fatal case of COVID-19 in Europe. This patient exhibited a rapid evolution towards multiorgan failure. SARS-CoV-2 was detected in multiple nasopharyngeal, blood, and pleural samples, despite antiviral and immunomodulator treatment. Clinical evolution in the blood was marked by an increase (2-3-fold) in differentiated effector T cells expressing exhaustion (PD-1) and senescence (CD57) markers, an expansion of antibody-secreting cells, a 15-fold increase in γδ T cell and proliferating NK-cell populations, and the total disappearance of monocytes, suggesting lung trafficking. In the serum, waves of a pro-inflammatory cytokine storm, Th1 and Th2 activation, and markers of T cell exhaustion, apoptosis, cell cytotoxicity, and endothelial activation were observed until the fatal outcome. This case underscores the need for well-designed studies to investigate complementary approaches to control viral replication, the source of the hyperinflammatory status, and immunomodulation to target the pathophysiological response. The investigation was conducted as part of an overall French clinical cohort assessing patients with COVID-19 and registered in clinicaltrials.gov under the following number: NCT04262921.
Complete list of metadata

Contributor : Boris Hejblum Connect in order to contact the contributor
Submitted on : Thursday, January 7, 2021 - 7:13:18 PM
Last modification on : Tuesday, December 21, 2021 - 2:50:05 PM


Files produced by the author(s)




Lila Bouadma, Aurélie Wiedemann, Juliette Patrier, Mathieu Surénaud, Paul-Henri Wicky, et al.. Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome. Journal of Clinical Immunology, Springer Verlag, 2020, 40, pp.1082-1092. ⟨10.1007/s10875-020-00839-x⟩. ⟨hal-03160737v2⟩



Record views


Files downloads