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PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study

Abstract : PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy. We assessed the safety and immunogenicity of PRIMVAC adjuvanted with Alhydrogel or glucopyranosyl lipid adjuvant in stable emulsion (GLA-SE) in French and Burkinabe women who were not pregnant.
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https://hal.inria.fr/hal-03161802
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Submitted on : Wednesday, December 2, 2020 - 10:12:16 AM
Last modification on : Thursday, April 7, 2022 - 1:58:31 PM
Long-term archiving on: : Wednesday, March 3, 2021 - 6:26:53 PM

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Sodiomon Sirima, Laura Richert, Arnaud Chêne, Amadou Konate, Cécilia Campion, et al.. PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study. The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2020, 20 (5), pp.585-597. ⟨10.1016/S1473-3099(19)30739-X⟩. ⟨hal-03161802v2⟩

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