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Patient specific tracts-based analysis of diffusion compartment models: application to multiple sclerosis patients with acute optic neuritis

Olivier Commowick 1 Renaud Hédouin 1 Charlotte Laurent 2 Jean-Christophe Ferré 1, 2
1 Empenn
INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : Multiple sclerosis is a complex disease where voxel-based, group-based statistics of the brain microstructure have shown their limits in explaining patient evolution. This is first due to too simple diffusion models, mixing information. Voxel-based studies also lack knowledge on brain structural connectivity. Finally, group-based analysis does not describe well the specific patient status (a crucial point for clinicians). We propose an atlas-based framework, combined with advanced diffusion compartment models, for patient specific analysis of microstructural disease burden on major fiber bundles. We apply our framework to the analysis of optic radiations of MS patients with acute optic neuritis.
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https://hal.inria.fr/hal-03202059
Contributor : Olivier Commowick <>
Submitted on : Monday, April 19, 2021 - 2:56:40 PM
Last modification on : Friday, April 30, 2021 - 3:05:32 AM

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  • HAL Id : hal-03202059, version 1

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Olivier Commowick, Renaud Hédouin, Charlotte Laurent, Jean-Christophe Ferré. Patient specific tracts-based analysis of diffusion compartment models: application to multiple sclerosis patients with acute optic neuritis. ISMRM 2021 - International Society for Magnetic Resonance in Medicine, May 2021, Toronto, Canada. pp.1-6. ⟨hal-03202059⟩

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