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SAMBA: a Novel Method for Fast Automatic Model Building in Nonlinear Mixed-Effects Models

Mélanie Prague 1, 2 Marc Lavielle 3 
2 SISTM - Statistics In System biology and Translational Medicine
Inria Bordeaux - Sud-Ouest, BPH - Bordeaux population health
3 XPOP - Modélisation en pharmacologie de population
CMAP - Centre de Mathématiques Appliquées - Ecole Polytechnique, Inria Saclay - Ile de France
Abstract : The success of correctly identifying all the components of a nonlinear mixed-effects model is far from straightforward: it is a question of finding the best structural model, determining the type of relationship between covariates and individual parameters, detecting possible correlations between random effects, or also modeling residual errors. We present the SAMBA (Stochastic Approximation for Model Building Algorithm) procedure and show how this algorithm can be used to speed up this process of model building by identifying at each step how best to improve some of the model components. The principle of this algorithm basically consists in 'learning something' about the 'best model', even when a 'poor model' is used to fit the data. A comparison study of the SAMBA procedure with SCM and COSSAC show similar performances on several real data examples but with a much-reduced computing time. This algorithm is now implemented in Monolix and in the R package Rsmlx.
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Submitted on : Saturday, October 30, 2021 - 5:27:53 PM
Last modification on : Friday, July 8, 2022 - 10:08:53 AM
Long-term archiving on: : Monday, January 31, 2022 - 6:46:54 PM


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Mélanie Prague, Marc Lavielle. SAMBA: a Novel Method for Fast Automatic Model Building in Nonlinear Mixed-Effects Models. CPT: Pharmacometrics and Systems Pharmacology, In press, ⟨10.1002/psp4.12742⟩. ⟨hal-03410025⟩



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