Skip to Main content Skip to Navigation
New interface
Journal articles

A model-strengthened imaging biomarker for survival prediction in EGFR-mutated non-small-cell lung carcinoma patients treated with tyrosine kinase inhibitors

Annabelle Collin 1, 2 Vladimir Groza Louise Missenard François Chomy Thierry Colin Jean Palussière Olivier Saut 1, 2 
2 MONC - Modélisation Mathématique pour l'Oncologie
IMB - Institut de Mathématiques de Bordeaux, Institut Bergonié [Bordeaux], Inria Bordeaux - Sud-Ouest
Abstract : Non-small-cell lung carcinoma is a frequent type of lung cancer with a bad prognosis. Depending on the stage, genomics, several therapeutical approaches are used. Tyrosine Kinase Inhibitors (TKI) may be successful for a time in the treatment of EGFR-mutated non-small cells lung carcinoma. Our objective is here to propose a survival assessment as their efficacy in the long run is challenging to evaluate. The study includes 17 patients diagnosed as of EGFR-mutated non-small cell lung cancer and exposed to an EGFR-targeting TKI with 3 computed tomography (CT) scans of the primitive tumor (one before the TKI introduction and two after). An imaging biomarker based on the texture heterogeneity evolution between the first and the third exams is derived and computed from a mathematical model and patient data. Defining the overall survival as the time between the introduction of the TKI treatment and the patient death, we obtain a statistically significant correlation between the overall survival and our imaging marker (p = 0:009). Using the ROC curve, the patients are separated into two populations and the comparison of the survival curves is statistically significant (p = 0:025). The baseline exam seems to have a significant role in the prediction of response to TKI treatment. More precisely, our imaging biomarker defined using only the CT scan before the TKI introduction allows to determine a first classification of the population which is improved over time using the imaging marker as soon as more CT scans are available. This exploratory study leads us to think that it is possible to obtain a survival assessment using only few CT scans of the primary tumor.
Complete list of metadata

https://hal.inria.fr/hal-03428532
Contributor : Olivier Saut Connect in order to contact the contributor
Submitted on : Monday, November 15, 2021 - 10:50:31 AM
Last modification on : Friday, July 8, 2022 - 10:06:07 AM
Long-term archiving on: : Wednesday, February 16, 2022 - 7:55:10 PM

File

EGFR-BMB.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Annabelle Collin, Vladimir Groza, Louise Missenard, François Chomy, Thierry Colin, et al.. A model-strengthened imaging biomarker for survival prediction in EGFR-mutated non-small-cell lung carcinoma patients treated with tyrosine kinase inhibitors. Bulletin of Mathematical Biology, 2021, 83 (6), ⟨10.1007/s11538-021-00902-7⟩. ⟨hal-03428532⟩

Share

Metrics

Record views

26

Files downloads

128