Addenbrooke Cognitive Examination-III and detection of Alzheimer's disease: a comparison of ACE-III, M-ACE and ECAS in a Greek Alzheimer's disease population - Archive ouverte HAL Access content directly
Journal Articles Journal of the International Neuropsychological Society Year : 2020

Addenbrooke Cognitive Examination-III and detection of Alzheimer's disease: a comparison of ACE-III, M-ACE and ECAS in a Greek Alzheimer's disease population

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Abstract

Introduction: The present study attempted to adapt into Greek and validate the Addenbrooke's Cognitive Examination-III (ACE-III) and Mini-ACE (M-ACE) against their predecessors Addenbrooke's Cognitive Examination-Revised (ACE-R) and Mini-Mental State Examination (MMSE) in an Alzheimer's disease (AD) population. Notably, the present study also aimed to appraise the utility of each screen by conducting a comparison of the psychometric properties of ACE-III, MACE , ACE-R, MMSE, and Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in detecting AD. Methods: Forty AD patients were recruited and matched with 38 controls. Bayes correlation analysis was conducted to examine convergent validity. Receiver operating characteristics curve analysis was implemented to appraise the sensitivity and specificity of the tests. Results: The ACE-III, MACE and ECAS and its sub-scores robustly correlated with ACE-R and MMSE. The ACE-III and the ECAS-ALS Non-Specific score were the most sensitive and specific tools in detecting AD, closely followed by ECAS Total score and MACE. Solely ECAS Total score correlated with the duration of disease. Discussion: ACE-III and MACE are validated and showed very good psychometric properties in detecting AD and may be considered in hectic clinical settings. ECAS total score and ECAS-ALS Non-Specific showed comparable psychometric properties and may be considered in poly-pathological clinics for the detection and monitoring of AD in patients with motor impairments common to neurodegenerative diseases.
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Dates and versions

hal-03473109 , version 1 (09-12-2021)

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Panagiotis Kourtesis, Eleni Margioti, Christina Demenega, Foteini Christidi, Sharon Abrahams. Addenbrooke Cognitive Examination-III and detection of Alzheimer's disease: a comparison of ACE-III, M-ACE and ECAS in a Greek Alzheimer's disease population. Journal of the International Neuropsychological Society, 2020, 26 (8), pp.825-834. ⟨10.1017/S1355617720000314⟩. ⟨hal-03473109⟩
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