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Journal Articles Scientific Reports Year : 2021

Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

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Trang Le
Alba Gutiérrez-Sacristán
Jiyeon Son
  • Function : Author
Chuan Hong
Andrew South
Brett Beaulieu-Jones
Ne Hooi Will Loh
Yuan Luo
Michele Morris
Kee Yuan Ngiam
Lav Patel
Malarkodi Samayamuthu
  • Function : Author
Emily Schriver
Amelia Tan
  • Function : Author
Jason Moore
Tianxi Cai
Gilbert Omenn
Paul Avillach
Isaac Kohane
Shyam Visweswaran
Danielle Mowery
Zongqi Xia
James Aaron
  • Function : Author
Giuseppe Agapito
  • Function : Author
Adem Albayrak
  • Function : Author
Mario Alessiani
  • Function : Author
Danilo Amendola
François Angoulvant
Li Anthony
  • Function : Author
Bruce Aronow
Andrew Atz
  • Function : Author
James Balshi
  • Function : Author
Douglas Bell
  • Function : Author
Antonio Bellasi
Riccardo Bellazzi
Vincent Benoit
  • Function : Author
Michele Beraghi
José Luis Bernal Sobrino
  • Function : Author
Mélodie Bernaux
  • Function : Author
Romain Bey
  • Function : Author
Alvar Blanco Martínez
  • Function : Author
Martin Boeker
  • Function : Author
Clara-Lea Bonzel
John Booth
  • Function : Author
Silvano Bosari
  • Function : Author
Florence Bourgeois
  • Function : Author
Robert Bradford
Gabriel Brat
Stéphane Bréant
  • Function : Author
Nicholas Brown
  • Function : Author
William Bryant
  • Function : Author
Mauro Bucalo
Anita Burgun
Mario Cannataro
Aldo Carmona
  • Function : Author
Charlotte Caucheteux
  • Function : Author
Julien Champ
  • Function : Author
Krista Chen
  • Function : Author
Jin Chen
  • Function : Author
Luca Chiovato
Lorenzo Chiudinelli
  • Function : Author
James Cimino
Tiago Colicchio
  • Function : Author
Sylvie Cormont
  • Function : Author
Sébastien Cossin
  • Function : Author
Jean Craig
  • Function : Author
Juan Luis Cruz Bermúdez
  • Function : Author
Jaime Cruz Rojo
  • Function : Author
Arianna Dagliati
Mohamad Daniar
Christel Daniel
  • Function : Author
Anahita Davoudi
  • Function : Author
Batsal Devkota
  • Function : Author
Julien Dubiel
  • Function : Author
Loic Esteve
  • Function : Author
Shirley Fan
  • Function : Author
Robert Follett
Paula Gaiolla
  • Function : Author
Thomas Ganslandt
  • Function : Author
Noelia García Barrio
Lana Garmire
  • Function : Author
Nils Gehlenborg
Alon Geva
  • Function : Author
Tobias Gradinger
  • Function : Author
Alexandre Gramfort
Romain Griffier
  • Function : Author
Nicolas Griffon
Olivier Grisel
  • Function : Author
David Hanauer
Christian Haverkamp
  • Function : Author
Bing He
  • Function : Author
Darren Henderson
Martin Hilka
  • Function : Author
John Holmes
Petar Horki
  • Function : Author
Kenneth Huling
  • Function : Author
Meghan Hutch
Richard Issitt
  • Function : Author
Anne Sophie Jannot
  • Function : Author
Vianney Jouhet
Ramakanth Kavuluru
Mark Keller
  • Function : Author
Katie Kirchoff
Jeffrey Klann
Ian Krantz
  • Function : Author
Detlef Kraska
  • Function : Author
Ashok Krishnamurthy
Sehi L’yi
  • Function : Author
Judith Leblanc
  • Function : Author
Andressa Leite
  • Function : Author
Guillaume Lemaitre
  • Function : Author
Leslie Lenert
  • Function : Author
Damien Leprovost
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  • PersonId : 782540
  • IdRef : 17128500X
Molei Liu
Sarah Lozano-Zahonero
  • Function : Author
Kristine Lynch
  • Function : Author
Sadiqa Mahmood
  • Function : Author
Sarah Maidlow
Adeline Makoudjou Tchendjou
  • Function : Author
Alberto Malovini
Kenneth Mandl
Chengsheng Mao
  • Function : Author
Anupama Maram
  • Function : Author
Patricia Martel
  • Function : Author
Aaron Masino
  • Function : Author
Michael Matheny
  • Function : Author
Thomas Maulhardt
  • Function : Author
Maria Mazzitelli
  • Function : Author
Michael Mcduffie
  • Function : Author
Arthur Mensch
  • Function : Author
Fatima Ashraf
  • Function : Author
Marianna Milano
  • Function : Author
Marcos Minicucci
  • Function : Author
Bertrand Moal
Cinta Moraleda
  • Function : Author
Jeffrey Morris
  • Function : Author
Karyn Moshal
  • Function : Author
Sajad Mousavi
  • Function : Author
Douglas Murad
  • Function : Author
Shawn Murphy
Thomas Naughton
  • Function : Author
James Norman
  • Function : Author
Jihad Obeid
  • Function : Author
Marina Okoshi
Karen Olson
  • Function : Author
Nina Orlova
  • Function : Author
Brian Ostasiewski
  • Function : Author
Nathan Palmer
Nicolas Paris
  • Function : Author
Miguel Pedrera Jimenez
  • Function : Author
Emily Pfaff
  • Function : Author
Danielle Pillion
  • Function : Author
Hans Prokosch
  • Function : Author
Robson Prudente
Víctor Quirós González
  • Function : Author
Rachel Ramoni
  • Function : Author
Maryna Raskin
  • Function : Author
Siegbert Rieg
  • Function : Author
Gustavo Roig Domínguez
  • Function : Author
Pablo Rojo
  • Function : Author
Carlos Sáez
  • Function : Author
Elisa Salamanca
  • Function : Author
Arnaud Sandrin
  • Function : Author
Janaina Santos
  • Function : Author
Maria Savino
  • Function : Author
Juergen Schuettler
  • Function : Author
Luigia Scudeller
  • Function : Author
Neil Sebire
  • Function : Author
Pablo Serrano Balazote
  • Function : Author
Patricia Serre
  • Function : Author
Arnaud Serret-Larmande
Zahra Shakeri
  • Function : Author
Domenick Silvio
  • Function : Author
Piotr Sliz
Charles Sonday
  • Function : Author
Anastasia Spiridou
  • Function : Author
Bryce Tan
  • Function : Author
Byorn Tan
  • Function : Author
Suzana Tanni
Deanne Taylor
Ana Terriza-Torres
  • Function : Author
Valentina Tibollo
Patric Tippmann
  • Function : Author
Carlo Torti
Enrico Trecarichi
  • Function : Author
Yi-Ju Tseng
  • Function : Author
Andrew Vallejos
Gael Varoquaux
  • Function : Author
Margaret Vella
  • Function : Author
Jill-Jênn Vie
  • Function : Author
Michele Vitacca
  • Function : Author
Kavishwar Wagholikar
Lemuel Waitman
  • Function : Author
Demian Wassermann
  • Function : Author
Griffin Weber
Yuan William
  • Function : Author
Nadir Yehya
  • Function : Author
Alberto Zambelli
  • Function : Author
Harrison Zhang
Daniela Zoeller
  • Function : Author
Chiara Zucco
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Abstract

Abstract Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January–September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7–7.8%, p FDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7–10.5%, p FDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19–25%), cerebrovascular diseases (24%, 13–35%), nontraumatic intracranial hemorrhage (34%, 20–50%), encephalitis and/or myelitis (37%, 17–60%) and myopathy (72%, 67–77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.

Dates and versions

hal-03476703 , version 1 (13-12-2021)

Identifiers

Cite

Trang Le, Alba Gutiérrez-Sacristán, Jiyeon Son, Chuan Hong, Andrew South, et al.. Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19. Scientific Reports, 2021, 11 (1), pp.20238. ⟨10.1038/s41598-021-99481-9⟩. ⟨hal-03476703⟩
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