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Journal Articles Journal of Allergy and Clinical Immunology: In Practice Year : 2021

Criteria for the Regression of Pediatric Mastocytosis: A Long-Term Follow-Up

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Abstract

Mastocytosis is a neoplastic condition characterized by the accumulation of mast cells (MCs) in 1 or more organ. Adults tend to have persistent, systemic mastocytosis, whereas MC infiltration in children is usually limited to the skin and typically regresses after several years. Both adults and children could display mast cell activation symptoms (MCASs) due to MC mediator release. In more than 85% of both adult and pediatric cases, KIT mutations are present, with the KIT D816V mutation being present in most affected adults but in only half the affected children.

Dates and versions

hal-03476810 , version 1 (13-12-2021)

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Laura Polivka, Julien Rossignol, Antoine Neuraz, Djiba Condé, Julie Agopian, et al.. Criteria for the Regression of Pediatric Mastocytosis: A Long-Term Follow-Up. Journal of Allergy and Clinical Immunology: In Practice, 2021, 9 (4), pp.1695-1704.e5. ⟨10.1016/j.jaip.2020.12.019⟩. ⟨hal-03476810⟩
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