Criteria for the Regression of Pediatric Mastocytosis: A Long-Term Follow-Up

Mastocytosis is a neoplastic condition characterized by the accumulation of mast cells (MCs) in 1 or more organ. Adults tend to have persistent, systemic mastocytosis, whereas MC infiltration in children is usually limited to the skin and typically regresses after several years. Both adults and children could display mast cell activation symptoms (MCASs) due to MC mediator release. In more than 85% of both adult and pediatric cases, KIT mutations are present, with the KIT D816V mutation being present in most affected adults but in only half the affected children.

Keywords

Cutaneous mastocytosis KIT mutation Mast cell Mast cell activation symptom Pediatric mastocytosis Prognosis Tryptase

Domains

Life Sciences [q-bio] Santé publique et épidémiologie

Antoine Neuraz : Connect in order to contact the contributor

https://hal.inria.fr/hal-03476810

Submitted on : Monday, December 13, 2021-10:57:45 AM

Last modification on : Friday, October 28, 2022-4:24:05 PM

Dates and versions

hal-03476810 , version 1 (13-12-2021)

Identifiers

HAL Id : hal-03476810 , version 1
DOI : 10.1016/j.jaip.2020.12.019
PUBMED : 33338682

Cite

Laura Polivka, Julien Rossignol, Antoine Neuraz, Djiba Condé, Julie Agopian, et al.. Criteria for the Regression of Pediatric Mastocytosis: A Long-Term Follow-Up. Journal of Allergy and Clinical Immunology: In Practice, 2021, 9 (4), pp.1695-1704.e5. ⟨10.1016/j.jaip.2020.12.019⟩. ⟨hal-03476810⟩

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