CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death
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Yves Lévy
- Function : Author
- PersonId : 759951
- ORCID : 0000-0002-4224-3137
Aurélie Wiedemann
- Function : Author
- PersonId : 759951
- ORCID : 0000-0002-4224-3137
Boris P. Hejblum
- Function : Author
- PersonId : 10465
- IdHAL : boris-hejblum
- ORCID : 0000-0003-0646-452X
- IdRef : 189970316
Cécile Lefebvre
- Function : Author
- PersonId : 779103
- ORCID : 0000-0002-6408-0201
Christine Lacabaratz
- Function : Author
- PersonId : 757905
- ORCID : 0000-0001-6925-0225
Marine Gauthier
- Function : Author
- PersonId : 801412
- ORCID : 0000-0002-4658-4051
Cédric Laouénan
- Function : Author
- PersonId : 771320
- ORCID : 0000-0002-3681-6314
- IdRef : 138946159
Jean-François Timsit
- Function : Author
- PersonId : 758651
- ORCID : 0000-0002-6063-7383
- IdRef : 077116313
Giuseppe Pantaleo
- Function : Author
- PersonId : 758701
- ORCID : 0000-0003-3651-2721
Rodolphe Thiébaut
- Function : Author
- PersonId : 175125
- IdHAL : rodolphe-thiebaut
- ORCID : 0000-0002-5235-3962
- IdRef : 071580735
Abstract
The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care.