A phase Ia/Ib clinical trial of metronomic chemotherapy based on a mathematical model of oral vinorelbine in metastatic non-small cell lung cancer and malignant pleural mesothelioma: rationale and study protocol

Metronomic oral vinorelbine is effective in metastatic NSCLC and malignant pleural mesothelioma, but all the studies published thus far were based upon a variety of empirical and possibly suboptimal schedules, with inconsistent results. Mathematical modelling showed by simulation that a new metronomic protocol could lead to a better safety and efficacy profile.

Mots clés

Modelling and simulation Vinorelbine Computational oncology Lung cancer Mesothelioma Metronomics

Domaines

Modélisation et simulation Analyse de données, Statistiques et Probabilités [physics.data-an] Cancer Pharmacologie Santé publique et épidémiologie Applications [stat.AP]

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s12885-016-2308-z.pdf (855.57 Ko)

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Joseph Ciccolini : Connectez-vous pour contacter le contributeur

https://hal.science/hal-03513050

Soumis le : mardi 19 décembre 2023-08:14:31

Dernière modification le : mardi 19 décembre 2023-15:49:11

Dates et versions

hal-03513050 , version 1 (19-12-2023)

Licence

Paternité

Identifiants

HAL Id : hal-03513050 , version 1
DOI : 10.1186/s12885-016-2308-z
PUBMED : 27094927
PUBMEDCENTRAL : PMC4837593

Citer

Xavier Elharrar, Dominique Barbolosi, Joseph Ciccolini, Christophe Meille, Christian Faivre, et al.. A phase Ia/Ib clinical trial of metronomic chemotherapy based on a mathematical model of oral vinorelbine in metastatic non-small cell lung cancer and malignant pleural mesothelioma: rationale and study protocol. BMC Cancer, 2016, 16 (1), pp.278. ⟨10.1186/s12885-016-2308-z⟩. ⟨hal-03513050⟩

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