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Simulation of Astrocytic Calcium Dynamics in Lattice Light Sheet Microscopy Images

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Abstract

Astrocytes regulate neuronal information processing through a variety of spatio-temporal calcium signals. Advances in calcium imaging started to reveal astrocytic activities, but the complexity of the recorded data strongly call for computational analysis tools. Their development is hindered by the lack of reliable annotations that are essential for their evaluation and for the design of learning-based methods. To overcome the labeling problem, we present a framework to simulate realistic astrocytic calcium signals in 3D+time lattice light sheet microscopy (LLSM) images by closely modeling calcium kinetics in real astrocytes.
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Dates and versions

hal-03516709 , version 1 (07-01-2022)

Identifiers

  • HAL Id : hal-03516709 , version 1

Cite

Anaïs Badoual, Misa Arizono, Audrey Denizot, Mathieu Ducros, Hugues Berry, et al.. Simulation of Astrocytic Calcium Dynamics in Lattice Light Sheet Microscopy Images. ISBI 2021 - IEEE International Symposium on Biomedical Imaging, Apr 2021, Nice, France. pp.1. ⟨hal-03516709⟩
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