Background. The incidence of cardiac dyspnea (CD) and the distribution of pollution in the south of France suggests that environmental pollution may have a role in disease triggering. CD is a hallmark symptom of heart failure leading to reduced ability to function and engage in activities of daily living. Methods. To show the impact of short-term pollution exposure on the increment of CD emergency room visits, we collected pollutants and climate measurements on a daily basis and 43,400 events of CD in the Région Sud from 2013 to 2018. We used a distributed lag non-linear model (DLNM) to assess the association between air pollution and CD events. We divided the region in 357 zones to reconciliate environmental and emergency room visits data. We applied the DLNM on the entire region, on zones grouped by pollution trends and on singular zones. Results. Each pollutant has a significant effect on triggering CD. Depending on the pollutant, we identified four shapes of exposure curves to describe the impact of pollution on CD events: early and late effect for NO 2 ; U-shape and rainbow-shape (or inverted U) for O 3 ; all the four shapes for PM10. In the biggest cities, O 3 has the most significant association along with the PM10. In the west side, a delayed effect triggered by PM10 was found. Zones along the main highway are mostly affected by NO 2 pollution with an increase of the association for a period up to 9 days after the pollution peak. Conclusions. Our results can be used by local authorities to set up specific prevention policies, public alerts that adapt to the different zones and support public health predictionmaking. We developed a user-friendly web application called HEART (Health, Environment in PACA Region Tool) to collect our results. HEART will allow citizens, researchers and local authorities to monitor the impact of pollution trends on local public health.