Optimal bacterial resource allocation
Résumé
The problem of synthesizing a metabolite of interest in continuous bioreac- tors through resource allocation control is addressed. The approach is based on a self-replicator dynamical model that accounts for microbial culture growth inside the bioreactor, and incorporates a synthetic growth switch that allows to externally modify the RNA polymerase concentration of the bacterial popula- tion. The optimal control problem exhibits two ubiquitous phenomena: Fuller and turnpike. Joint work with J.-L. Gouzé and A. Yabo (Sophia).
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