This paper examines the average age minimization problem where only a fraction of the network users can transmit simultaneously over unreliable channels. Finding the optimal scheduling scheme, in this case, is known to be challenging. Accordingly, the Whittle’s index policy was proposed in the literature as a low-complexity heuristic to the problem. Although simple to implement, characterizing this policy’s performance is recognized to be a notoriously tricky task. In the sequel, we provide a new mathematical approach to establish its optimality in the many-users regime for specific network settings. Contrary to previous works in the literature that use restrictive mathematical assumptions, which can be challenging to verify, our novel approach is based on intricate techniques and it is free of any strong mathematical assumptions. These findings showcase that the Whittle’s index policy has analytically provable asymptotic optimality for the AoI minimization problem. Finally, we lay out numerical results that corroborate our theoretical findings and demonstrate the policy’s notable performance in the many-users regime.