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A multi-scale constraint programming model of alternative splicing regulation

Damien Eveillard 1, 2 Delphine Ropers 2, 3 Hidde de Jong 3 Christiane Branlant 2 Alexander Bockmayr 1
1 MODBIO - Computational models in molecular biology
INRIA Lorraine, LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications
3 HELIX - Computer science and genomics
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Alternative splicing is a key process in post-transcriptional regulation, by which different mature RNA can be obtained from the same premessenger RNA. The resulting combinatorial complexity contributes to biological diversity, especially in the case of the human immunodeficiency virus HIV-1. Using a constraint programming approach, we develop a model of the alternative splicing regulation in HIV-1. Our model integrates different scales (single site vs. multiple sites), and thus allows us to exploit several types of experimental data available to us.
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Contributor : Damien Eveillard <>
Submitted on : Thursday, December 8, 2005 - 6:22:12 PM
Last modification on : Friday, January 8, 2021 - 11:22:05 AM



Damien Eveillard, Delphine Ropers, Hidde de Jong, Christiane Branlant, Alexander Bockmayr. A multi-scale constraint programming model of alternative splicing regulation. Theoretical Computer Science, Elsevier, 2004, Special issue: computational systems biology, 325 (1), pp.3-24. ⟨10.1016/j.tcs.2004.03.062⟩. ⟨inria-00000916⟩



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