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Building and analysing an integrative model of HIV-1 RNA alternative splicing

Alexander Bockmayr 1 Arnaud Courtois 1 Damien Eveillard 1, 2 Myriam Vezain 1
1 MODBIO - Computational models in molecular biology
INRIA Lorraine, LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications
2 MAEM - Maturation des ARN et enzymologie moléculaire
Abstract : We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.
Keywords : constraints hybrid system qualitative reasoning alternative splicing
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Conference papers
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https://hal.inria.fr/inria-00000917
Contributor : Damien Eveillard <>
Submitted on : Thursday, December 8, 2005 - 6:34:47 PM
Last modification on : Monday, February 17, 2020 - 3:50:19 PM

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Alexander Bockmayr, Arnaud Courtois, Damien Eveillard, Myriam Vezain. Building and analysing an integrative model of HIV-1 RNA alternative splicing. International Conference on Computational Methods in Systems Biology - CMSB 2004, May 2004, Paris/France, pp.43--57, ⟨10.1007/b107287⟩. ⟨inria-00000917⟩

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