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Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks

Samuel Drulhe 1, 2 Giancarlo Ferrari-Trecate 3 Hidde de Jong 1 Alain Viari 1 
1 HELIX - Computer science and genomics
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this paper, we present an approach for the identification of PieceWise-Affine (PWA) models of genetic regulatory networks from experimental data, focusing on the reconstruction of switching thresholds associated with regulatory interactions. In particular, our method takes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.
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https://hal.inria.fr/inria-00001225
Contributor : Samuel Drulhe Connect in order to contact the contributor
Submitted on : Friday, April 14, 2006 - 3:54:37 PM
Last modification on : Tuesday, October 25, 2022 - 4:20:12 PM
Long-term archiving on: : Saturday, April 3, 2010 - 11:09:32 PM

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Samuel Drulhe, Giancarlo Ferrari-Trecate, Hidde de Jong, Alain Viari. Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks. Hybrid Systems: Computation and Control, HSCC 2006, Mar 2006, Santa Barbara, CA, USA, pp.184 - 199, ⟨10.1007/11730637⟩. ⟨inria-00001225⟩

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