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A Multi-Site Constraint Programming Model of Alternative Splicing Regulation

Damien Eveillard 1 Delphine Ropers 2 Hidde de Jong Christiane Branlant Alexander Bockmayr 1
1 MODBIO - Computational models in molecular biology
INRIA Lorraine, LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications
2 HELIX - Computer science and genomics
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Alternative splicing is a key process in post-transcriptional regulation, by which several kinds of mature RNA can be obtained from the same premessenger RNA. The resulting combinatorial complexity contributes to biological diversity, especially in the case of the human immunodeficiency virus HIV-1. Using a constraint programming approach, we develop a model of the alternative splicing regulation in HIV-1. Our model integrates different scales (single site vs. multiple sites), and thus allows us to exploit several types of experimental data available to us.
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https://hal.inria.fr/inria-00071756
Contributor : Rapport de Recherche Inria <>
Submitted on : Tuesday, May 23, 2006 - 6:41:53 PM
Last modification on : Monday, February 17, 2020 - 3:50:19 PM
Long-term archiving on: : Sunday, April 4, 2010 - 10:36:38 PM

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  • HAL Id : inria-00071756, version 1

Citation

Damien Eveillard, Delphine Ropers, Hidde de Jong, Christiane Branlant, Alexander Bockmayr. A Multi-Site Constraint Programming Model of Alternative Splicing Regulation. [Research Report] RR-4830, INRIA. 2003. ⟨inria-00071756⟩

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