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Qualitative Simulation of the Initiation of Sporulation in B. subtilis

Hidde De jong 1 Johannes Geiselmann 2 Grégory Batt 1 Céline Hernandez 1 Michel Page 1
1 HELIX - Computer science and genomics
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Under conditions of nutrient deprivation, the Gram positive soil bacterium Bacillus subtilis can abandon vegetative growth and form a dormant, environmen- tally-resistant spore instead. The decision to either divide or sporulate is controlled by a large and complex genetic regulatory network integrating various environmental, cell-cycle, and metabolic signals. Although sporulation in B. subtilis is one of the best-understood model systems for prokaryotic development, very little quantitative data on kinetic parameters and molecular concentrations are available. A qualitative simulation method is used to model the sporulation network and simulate the response of the cell to nutrient deprivation. Using this method, we have been able to reproduce essential features of the choice between vegetativ- e growth and sporulation, in particular the role played by competing positive and negative feedback loops.
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https://hal.inria.fr/inria-00072061
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Submitted on : Tuesday, May 23, 2006 - 7:40:34 PM
Last modification on : Friday, February 4, 2022 - 3:32:31 AM
Long-term archiving on: : Sunday, April 4, 2010 - 8:28:20 PM

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Hidde De jong, Johannes Geiselmann, Grégory Batt, Céline Hernandez, Michel Page. Qualitative Simulation of the Initiation of Sporulation in B. subtilis. [Research Report] RR-4527, INRIA. 2002. ⟨inria-00072061⟩

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