Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks

Samuel Drulhe 1, 2 Hidde De Jong 1 Giancarlo Ferrari-Trecate 3
1 HELIX - Computer science and genomics
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive
Abstract : Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this paper, we present an approach for the identification of PieceWise-Affine (PWA) models of genetic regulatory networks from experimental data, focusing on the reconstruction of switching thresholds associated with regulatory interactions. In particular, our method takes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.
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Rapport
[Technical Report] RT-0322, INRIA. 2006, pp.25
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Soumis le : mardi 27 juin 2006 - 11:05:41
Dernière modification le : jeudi 19 avril 2018 - 14:49:42
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Samuel Drulhe, Hidde De Jong, Giancarlo Ferrari-Trecate. Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks. [Technical Report] RT-0322, INRIA. 2006, pp.25. 〈inria-00081608v2〉

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