Information found in the literature presents only marginal experiences concerning telemedicine in regards to peritoneal dialysis (PD). These experiences are limited to the transmission of data and/or images using new methods of communication. This article presents a new and innovative application of telemedicine in the field of PD and describes its characteristics in comparison to other telemedicine systems. In addition to optimizing the transmission of data via intra/internet, the DIATELIC (Interactive and Cooperative Monitoring of Dialysis Patients) system has an expert system designed to detect anomalies which can appear progressively and imperceptibly. This intelligent expert system uses six rules of interpretation simultaneously using basic initial data: Weight, blood pressure, differential blood pressure, orthostatic blood pressure, peritoneal ultrafiltration. These rules enable the system to give warning signs based on values which are pre-established or calculated using the averages of the previous 15 days. Routine use of this system operational now for over a year is conclusive. For the doctor, this system radically changes the way medical team follow-up on the patient. Daily access to the information concerning the patient resembles more a hospital-like setting and the integrated message service facilitates the contacts. For the patient, the sense of security derived from the expert system which notifies both the center and the patient in case of an anomaly is often mentioned. Telemedicine, which is in full development, will likely represent a major revolution for the public health system when the studies on the cost/benefit ratio reveal its utility.