Skip to Main content Skip to Navigation
Journal articles

Intersurf: dynamic interface between proteins

Abstract : Protein docking is a fundamental biological process that links two proteins. This link is typically defined by an interaction between two large zones of the protein boundaries. Visualizing such an interface is useful to understand the process thanks to 3D protein structures, to estimate the quality of docking simulation results, and to classify interactions in order to predict docking affinity between classes of interacting zones. Since the interface may be defined by a surface that separates the two proteins, it is possible to create a map of interaction that allows comparisons to be performed in 2D. This paper presents a very fast algorithm that extracts an interface surface and creates a valid and low-distorted interaction map. Another benefit of our approach is that a pre-computed part of the algorithm enables the surface to be updated in real-time while residues are moved.
Document type :
Journal articles
Complete list of metadata

Cited literature [9 references]  Display  Hide  Download

https://hal.inria.fr/inria-00105634
Contributor : Nicolas Ray <>
Submitted on : Wednesday, October 11, 2006 - 4:46:22 PM
Last modification on : Friday, February 26, 2021 - 3:28:03 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 7:25:09 PM

Identifiers

Citation

Nicolas Ray, Xavier Cavin, Jean-Claude Paul, Bernard Maigret. Intersurf: dynamic interface between proteins. Journal of Molecular Graphics and Modelling, Elsevier, 2005, 23 (4), pp.347-354. ⟨10.1016/j.jmgm.2004.11.004⟩. ⟨inria-00105634⟩

Share

Metrics

Record views

441

Files downloads

695