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Identification of reaction networks for bioprocesses: determination of a partially unknown pseudo-stoichiometric matrix

Olivier Bernard 1 Georges Bastin 2
1 COMORE - Modeling and control of renewable resources
LOV - Laboratoire d'océanographie de Villefranche, CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : In this paper we propose a methodology to determine the structure of the pseudo-stoichiometric co- efficient matrix K in a mass balance based model and to identify its coefficients from a set of available data. The first stage consists in estimating the number of re- actions that must be taken into account to represent the main mass transfer within the bioreactor. This provides the dimension of K. Then we propose a method to di- rectly determine the structure of the matrix (i.e. mainly its zeros and the signs of its coefficients). These meth- ods are illustrated with simulations of a process of lipase production from olive oil by Candida rugosa.
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Olivier Bernard, Georges Bastin. Identification of reaction networks for bioprocesses: determination of a partially unknown pseudo-stoichiometric matrix. Bioprocess and Biosystems Engineering, Springer Verlag, 2005, 27, pp.293-302. ⟨inria-00122549⟩

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