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The White Matter Integrity Disruption in Schizophrenia

Abstract : Diffusion tensor imaging studies in schizophrenia have demonstrated lower diffusion anisotropy within white matter that provides information about brain white matter integrity. We have examined whether white matter is abnormal in first-episode schizophrenia by using diffusion tensor imaging. Twenty-one schizophrenic patients and healthy controls underwent diffusion tensor imaging scans that analyzed by using a rigorous voxel-based approach. We found that fractional anisotropy in white matter of the patients was lower than that in controls at the cerebral peduncle, frontal regions, inferior temporal gyrus, medial parietal lobes, hippocampal gyrus, insula, right anterior cingulun bundle and right corona radiata. These results suggested that white matter integrity of the whole brain was disrupted in early illness onset of schizophrenia.
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Journal articles
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Contributor : Chine Publications Liama <>
Submitted on : Thursday, January 11, 2007 - 9:27:07 AM
Last modification on : Saturday, May 30, 2020 - 11:18:31 AM


  • HAL Id : inria-00123768, version 1
  • PRODINRA : 252043



Yihui Hao, Zhening Liu, Tianzi Jiang, Gaolang Gong, Haihong Liu, et al.. The White Matter Integrity Disruption in Schizophrenia. NeuroReport, Lippincott, Williams & Wilkins, 2006, NeuroReport, 17 (1), pp.23-26. ⟨inria-00123768⟩



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