Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling

Hugues Berry 1
1 ALCHEMY - Architectures, Languages and Compilers to Harness the End of Moore Years
LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, Inria Saclay - Ile de France, CNRS - Centre National de la Recherche Scientifique : UMR8623
Abstract : Auto/paracrine cell-to-cell communications via diffusive messengers can be coupled to a positive feedback loop in which cell stimulation by a messenger results in the production of new messengers. This yields a potential mechanism for relay transmission of the emitted message. This paper investigates the influence of noise on this mutual coupling of the cells with their environment, using numerical simulations of a stochastic minimal model. The results demonstrate that the deterministic (mean-field) approximation of this stochastic process fails short of predicting its behaviour because of the presence of strong noise-induced fluctuations. Instead, the behaviour of the model can be explained by the occurrence of a nonequilibrium phase transition, which is found to be in the universality class of directed percolation. This provides a theoretical framework to understand signal transmission in these stochastic systems.
Liste complète des métadonnées

Littérature citée [37 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/inria-00201086
Contributeur : Hugues Berry <>
Soumis le : dimanche 23 décembre 2007 - 12:09:56
Dernière modification le : jeudi 11 janvier 2018 - 01:49:34
Document(s) archivé(s) le : mardi 13 avril 2010 - 15:25:13

Fichiers

PhaseTransBerry_2008.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : inria-00201086, version 1

Citation

Hugues Berry. Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling. 2007. 〈inria-00201086〉

Partager

Métriques

Consultations de la notice

293

Téléchargements de fichiers

75