HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Preprints, Working Papers, ...

Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling

Hugues Berry 1
1 ALCHEMY - Architectures, Languages and Compilers to Harness the End of Moore Years
LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, CNRS - Centre National de la Recherche Scientifique : UMR8623, Inria Saclay - Ile de France
Abstract : Auto/paracrine cell-to-cell communications via diffusive messengers can be coupled to a positive feedback loop in which cell stimulation by a messenger results in the production of new messengers. This yields a potential mechanism for relay transmission of the emitted message. This paper investigates the influence of noise on this mutual coupling of the cells with their environment, using numerical simulations of a stochastic minimal model. The results demonstrate that the deterministic (mean-field) approximation of this stochastic process fails short of predicting its behaviour because of the presence of strong noise-induced fluctuations. Instead, the behaviour of the model can be explained by the occurrence of a nonequilibrium phase transition, which is found to be in the universality class of directed percolation. This provides a theoretical framework to understand signal transmission in these stochastic systems.
Complete list of metadata

Cited literature [37 references]  Display  Hide  Download

Contributor : Hugues Berry Connect in order to contact the contributor
Submitted on : Sunday, December 23, 2007 - 12:09:56 PM
Last modification on : Friday, February 4, 2022 - 3:30:18 AM
Long-term archiving on: : Tuesday, April 13, 2010 - 3:25:13 PM


Files produced by the author(s)


  • HAL Id : inria-00201086, version 1


Hugues Berry. Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling. 2007. ⟨inria-00201086⟩



Record views


Files downloads