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Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling

Hugues Berry 1
1 ALCHEMY - Architectures, Languages and Compilers to Harness the End of Moore Years
LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, CNRS - Centre National de la Recherche Scientifique : UMR8623, Inria Saclay - Ile de France
Abstract : Auto/paracrine cell-to-cell communications via diffusive messengers can be coupled to a positive feedback loop in which cell stimulation by a messenger results in the production of new messengers. This yields a potential mechanism for relay transmission of the emitted message. This paper investigates the influence of noise on this mutual coupling of the cells with their environment, using numerical simulations of a stochastic minimal model. The results demonstrate that the deterministic (mean-field) approximation of this stochastic process fails short of predicting its behaviour because of the presence of strong noise-induced fluctuations. Instead, the behaviour of the model can be explained by the occurrence of a nonequilibrium phase transition, which is found to be in the universality class of directed percolation. This provides a theoretical framework to understand signal transmission in these stochastic systems.
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Submitted on : Sunday, December 23, 2007 - 12:09:56 PM
Last modification on : Friday, February 4, 2022 - 3:30:18 AM
Long-term archiving on: : Tuesday, April 13, 2010 - 3:25:13 PM

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Hugues Berry. Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling. 2007. ⟨inria-00201086⟩

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