From Molecules to Organisms: Towards Multiscale Integrated Models of Biological Systems

Christophe Lavelle 1, 2, 3 Hugues Berry 4 Guillaume Beslon 5, 6 Francisco Ginelli 7 Jean-Louis Giavitto 8 Zoi Kapoula 9 André Le Bivic 10, 11 Nadine Peyriéras 12, 13 Ovidiu Radulescu 14, 15 Adrien Six 16 Véronique Thomas-Vaslin 17 Paul Bourgine 18
4 ALCHEMY - Architectures, Languages and Compilers to Harness the End of Moore Years
LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, CNRS - Centre National de la Recherche Scientifique : UMR8623, Inria Saclay - Ile de France
5 DM2L - Data Mining and Machine Learning
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
6 COMBINING - COMputational BIology and data miNING
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes
8 COSMO
IBISC - Informatique, Biologie Intégrative et Systèmes Complexes
10 NNMDDCA - NMDA : Neurogenèse et morphogenèse dans le développement et chez l'adulte
CNRS - Centre National de la Recherche Scientifique : UMR6156, Université de la Méditerranée - Aix-Marseille 2
15 SYMBIOSE - Biological systems and models, bioinformatics and sequences
IRISA - Institut de Recherche en Informatique et Systèmes Aléatoires, Inria Rennes – Bretagne Atlantique
Abstract : A consensus has recently emerged that further progress in understanding human physiopathology will demand integrative views of biological systems. In this context, complex systems and related interdisciplinary approaches of biology are expected to help. The aim of this collective paper is basically to provide a starting point for further discussions and interactions within the community of complex systems biologists. After briefly introducing some general concepts, we present four major challenges that should be tackled in the next years. These represent future directions that we isolated as priority concerns for modern biology. Suggestions of how to reach these destinations are provided, with the hope that they will soon lead to concrete advances towards fully consistent multiscale models of biological systems and a better understanding of physiopathology.
Type de document :
Article dans une revue
Theoretical Biology Insights, Libertas Academica, 2008, 1, pp.13-22
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https://hal.inria.fr/inria-00331281
Contributeur : Ovidiu Radulescu <>
Soumis le : jeudi 16 octobre 2008 - 10:31:13
Dernière modification le : jeudi 18 janvier 2018 - 01:36:06

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  • HAL Id : inria-00331281, version 1

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Christophe Lavelle, Hugues Berry, Guillaume Beslon, Francisco Ginelli, Jean-Louis Giavitto, et al.. From Molecules to Organisms: Towards Multiscale Integrated Models of Biological Systems. Theoretical Biology Insights, Libertas Academica, 2008, 1, pp.13-22. 〈inria-00331281〉

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