Validation of a morphogenesis model of Drosophila early development by a multi-objective evolutionary optimization algorithm

Rui Dilão 1 Daniele Muraro 1 Miguel Nicolau 2, 3 Marc Schoenauer 2, 3
3 TAO - Machine Learning and Optimisation
LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, Inria Saclay - Ile de France, CNRS - Centre National de la Recherche Scientifique : UMR8623
Abstract : We apply evolutionary computation to calibrate the parameters of a morphogenesis model of Drosophila early development. The model aims to describe the establishment of the steady gradients of Bicoid and Caudal proteins along the antero-posterior axis of the embryo of Drosophila. The model equations consist of a system of non-linear parabolic partial differential equations with initial and zero flux boundary conditions. We compare the results of single- and multi-objective variants of the CMA-ES algorithm for the model the calibration with the experimental data. Whereas the multi-objective algorithm computes a full approximation of the Pareto front, repeated runs of the single-objective algorithm give solutions that dominate (in the Pareto sense) the results of the multi-objective approach. We retain as best solutions those found by the latter technique. From the biological point of view, all such solutions are all equally acceptable, and for our test cases, the relative error between the experimental data and validated model solutions on the Pareto front are in the range 3%-6%. This technique is general and can be used as a generic tool for parameter calibration problems.
Type de document :
Communication dans un congrès
European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, Apr 2009, Tübingen, Germany. pp.176-190, 2009
Liste complète des métadonnées

https://hal.inria.fr/inria-00378037
Contributeur : Miguel Nicolau <>
Soumis le : jeudi 23 avril 2009 - 14:29:57
Dernière modification le : jeudi 9 février 2017 - 15:54:35
Document(s) archivé(s) le : jeudi 10 juin 2010 - 21:39:49

Identifiants

  • HAL Id : inria-00378037, version 1

Collections

Citation

Rui Dilão, Daniele Muraro, Miguel Nicolau, Marc Schoenauer. Validation of a morphogenesis model of Drosophila early development by a multi-objective evolutionary optimization algorithm. European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, Apr 2009, Tübingen, Germany. pp.176-190, 2009. <inria-00378037>

Partager

Métriques

Consultations de
la notice

252

Téléchargements du document

803