Diffusion abnormalities in the primary sensorimotor pathways in writer's cramp.

Christine Delmaire 1 Marie Vidailhet 2 Demian Wassermann 3 Maxime Descoteaux 4 Romain Valabregue 5 Frédéric Bourdain 6 Christophe Lenglet 7 Sophie Sangla 8 Axel Terrier 9 Rachid Deriche 3 Stéphane Lehéricy 10
1 Services de neuroradiologie [Lille]
2 Neurologie et thérapeutique expérimentale
3 ODYSSEE - Computer and biological vision
DI-ENS - Département d'informatique de l'École normale supérieure, CRISAM - Inria Sophia Antipolis - Méditerranée , ENS Paris - École normale supérieure - Paris, Inria Paris-Rocquencourt, ENPC - École des Ponts ParisTech
4 NEUROSPIN - Service NEUROSPIN
5 CENIR - Centre de Neuro-Imagerie de Recherche
6 Service de neurologie [Univ. Paris VI]
7 Siemens Corporate Research
8 Service de neurologie 1 [CHU Pitié-Salpétrière]
9 Service d'anesthésie réanimation chirurgicale
10 Service de neuro-radiologie [CHU Pitié-Salpêtrière]
Abstract : OBJECTIVE: To determine whether there are diffusion abnormalities along the fibers connecting sensorimotor regions, including the primary sensorimotor areas and the striatum, in patients with writer's cramp using voxel-based diffusion analysis and fiber tracking. Recent studies have shown structural changes in these regions in writer's cramp. DESIGN: Patient and control group comparison. SETTING: Referral center for movement disorders. PARTICIPANTS: Twenty-six right-handed patients with writer's cramp and 26 right-handed healthy control subjects matched for sex and age. INTERVENTIONS: Clinical motor evaluations. MAIN OUTCOME MEASURES: Fractional anisotropy changes and results of fiber tracking in writer's cramp. RESULTS: Diffusion-tensor imaging revealed increased fractional anisotropy bilaterally in the white matter of the posterior limb of the internal capsule and adjacent structures in the patients with writer's cramp. Fiber tracking demonstrated that fractional anisotropy changes involve fiber tracts connecting the primary sensorimotor areas with subcortical structures. CONCLUSIONS: Diffusion abnormalities are present in fiber tracts connecting the primary sensorimotor areas with subcortical structures in writer's cramp. These abnormalities strengthen the role of the corticosubcortical pathways in the pathophysiologic mechanisms of writer's cramp.
Type de document :
Article dans une revue
Archives of Neurology -Chigago-, American Medical Association, 2009, 66 (4), pp.502-8. 〈10.1001/archneurol.2009.8〉
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https://hal.inria.fr/inria-00423384
Contributeur : Alain Monteil <>
Soumis le : vendredi 9 octobre 2009 - 16:43:59
Dernière modification le : vendredi 31 août 2018 - 08:47:30

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Christine Delmaire, Marie Vidailhet, Demian Wassermann, Maxime Descoteaux, Romain Valabregue, et al.. Diffusion abnormalities in the primary sensorimotor pathways in writer's cramp.. Archives of Neurology -Chigago-, American Medical Association, 2009, 66 (4), pp.502-8. 〈10.1001/archneurol.2009.8〉. 〈inria-00423384〉

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