Comparing Voronoi and Laguerre tessellations in the protein-protein docking context

Abstract : Most proteins fulfill their functions through the interaction with other proteins. Because most of these interactions are transitory, they are difficult to detect experimentally, and obtaining the structure of the complex is generally not possible. Consequently, prediction of the existence of these interactions and of the structure of the resulting complex has received a lot of attention in the last decade. However, proteins are very complex objects, and classical computing methods have lead to computer-time consuming methods, whose accuracy is not sufficient for largescale exploration of the so-called “interactome”, the ensemble of protein-protein complexes in the cell. In order to design an accurate and high-throughput prediction method for protein-protein docking, the first step was to model a protein structure using a formalism allowing fast computation, without losing the intrinsic properties of the object. In our work, we have tested two different, but related, formalisms: the Voronoi and Laguerre tessellations. We present here a comparison of these two models in the context of protein-protein docking.
Type de document :
Communication dans un congrès
Sixth annual International Symposium on Voronoi Diagrams, Jun 2009, Copenhagen, Denmark. 2009
Liste complète des métadonnées

Littérature citée [20 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/inria-00429618
Contributeur : Julie Bernauer <>
Soumis le : mardi 3 novembre 2009 - 16:46:09
Dernière modification le : jeudi 5 avril 2018 - 12:30:08
Document(s) archivé(s) le : jeudi 17 juin 2010 - 19:14:39

Fichier

2009_ISVD.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : inria-00429618, version 1

Collections

Citation

Thomas Bourquard, Julie Bernauer, Jérôme Azé, Anne Poupon. Comparing Voronoi and Laguerre tessellations in the protein-protein docking context. Sixth annual International Symposium on Voronoi Diagrams, Jun 2009, Copenhagen, Denmark. 2009. 〈inria-00429618〉

Partager

Métriques

Consultations de la notice

556

Téléchargements de fichiers

398