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Numerical studies on the effect of electric pulses on an egg-shaped cell with a spherical nucleus

François Buret 1 Nicolas Faure 1 Laurent Nicolas 1 Ronan Perrussel 1, * Clair Poignard 2, 3, *
* Corresponding author
3 MC2 - Modélisation, contrôle et calcul
Inria Bordeaux - Sud-Ouest, UB - Université de Bordeaux, CNRS - Centre National de la Recherche Scientifique : UMR5251
Abstract : In this paper, we study the influence of nanosecond electrical pulses on the phenomena arising in a biological cell model composed of a nucleus embedded in a cytoplasm, both entities being surrounded by a thin resistive membrane. The time-harmonic and the time-transient equations of the electric potential are presented, and accurate approximations of these equations are given, that avoid to mesh the thin resistive membranes. Numerical formulations of the partial differential equations are derived and simulations are performed in order to study the sensitivity of an eukaryotic cell to the orientation, the amplitude and the duration of the applied electric pulses.
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Submitted on : Thursday, April 29, 2010 - 12:36:43 PM
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François Buret, Nicolas Faure, Laurent Nicolas, Ronan Perrussel, Clair Poignard. Numerical studies on the effect of electric pulses on an egg-shaped cell with a spherical nucleus. [Research Report] RR-7270, Inria Bordeaux Sud-Ouest; INRIA. 2010, pp.21. ⟨inria-00477495⟩

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