Mucus dynamics subject to air and wall motion

S. Enault D. Lombardi Philippe Poncet 1, * Marc Thiriet 2, 3
* Corresponding author
3 REO - Numerical simulation of biological flows
LJLL - Laboratoire Jacques-Louis Lions, Inria Paris-Rocquencourt, UPMC - Université Pierre et Marie Curie - Paris 6
Abstract : This study presents a numerical investigation of basic interactions between respiratory mucus motion, air circulation and epithelium ciliated cells vibration. One focuses on identification of meaningful rheological parameters, physiological and numerical simulation dimensioning. These preliminary results are crucial before the study of more general configurations of respiratory mucus motion. The numerical study presented in this work aims at providing a first numerical tool able to simulate the effects of mucus mobility and its ability to carry out pathogens or to deliver aerosol therapy to membrane wall cells. Momentum diffusion is identified as the dominant effect, as expected in this micrometer scale configuration, and its associate momentum diffusion operator is shown to be extremely stiff. Furthermore, epithelium vibration is shown to be much more efficient than air circulation for mucus propulsion.
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https://hal.inria.fr/inria-00543082
Contributor : Marc Thiriet <>
Submitted on : Sunday, December 5, 2010 - 5:58:02 PM
Last modification on : Wednesday, May 15, 2019 - 3:49:38 AM

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  • HAL Id : inria-00543082, version 1

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S. Enault, D. Lombardi, Philippe Poncet, Marc Thiriet. Mucus dynamics subject to air and wall motion. ESAIM: Proceedings, EDP Sciences, 2010, 30, pp.125-141. ⟨inria-00543082⟩

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