# Inferring sparse Gaussian graphical models with latent structure

Abstract : Our concern is selecting the concentration matrix's nonzero coefficients for a sparse Gaussian graphical model in a high-dimensional setting. This corresponds to estimating the graph of conditional dependencies between the variables. We describe a novel framework taking into account a latent structure on the concentration matrix. This latent structure is used to drive a penalty matrix and thus to recover a graphical model with a constrained topology. Our method uses an $\ell_1$ penalized likelihood criterion. Inference of the graph of conditional dependencies between the variates and of the hidden variables is performed simultaneously in an iterative \textsc{em}-like algorithm. The performances of our method is illustrated on synthetic as well as real data, the latter concerning breast cancer.
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Cited literature [37 references]

https://hal.inria.fr/inria-00591491
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### Citation

Christophe Ambroise, Julien Chiquet, Catherine Matias. Inferring sparse Gaussian graphical models with latent structure. Electronic Journal of Statistics , Shaker Heights, OH : Institute of Mathematical Statistics, 2009, ⟨10.1214/08-EJS314⟩. ⟨inria-00591491⟩

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