Skip to Main content Skip to Navigation
New interface
Journal articles

An Electromechanical Model of the Heart for Image Analysis and Simulation

Maxime Sermesant 1, * Hervé Delingette 1, * Nicholas Ayache 1, * 
* Corresponding author
1 ASCLEPIOS - Analysis and Simulation of Biomedical Images
CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : This paper presents a new three-dimensional electromechanical model of the two cardiac ventricles designed both for the simulation of their electrical and mechanical activity, and for the segmentation of time series of medical images. First, we present the volumetric biomechanical models built. Then the transmembrane potential propagation is simulated, based on FitzHugh-Nagumo reaction-diffusion equations. The myocardium contraction is modeled through a constitutive law including an electromechanical coupling. Simulation of a cardiac cycle, with boundary conditions representing blood pressure and volume constraints, leads to the correct estimation of global and local parameters of the cardiac function. This model enables the introduction of pathologies and the simulation of electrophysiology interventions. Moreover, it can be used for cardiac image analysis. A new proactive deformable model of the heart is introduced to segment the two ventricles in time series of cardiac images. Preliminary results indicate that this proactive model, which integrates a priori knowledge on the cardiac anatomy and on its dynamical behavior, can improve the accuracy and robustness of the extraction of functional parameters from cardiac images even in the presence of noisy or sparse data. Such a model also allows the simulation of cardiovascular pathologies in order to test therapy strategies and to plan interventions.
Complete list of metadata

Cited literature [70 references]  Display  Hide  Download
Contributor : Project-Team Asclepios Connect in order to contact the contributor
Submitted on : Wednesday, August 17, 2011 - 9:11:40 PM
Last modification on : Saturday, June 25, 2022 - 11:06:31 PM
Long-term archiving on: : Friday, November 25, 2011 - 11:25:13 AM


Files produced by the author(s)


  • HAL Id : inria-00614991, version 1



Maxime Sermesant, Hervé Delingette, Nicholas Ayache. An Electromechanical Model of the Heart for Image Analysis and Simulation. IEEE Transactions on Medical Imaging, 2006, 25 (5), pp.612-625. ⟨inria-00614991⟩



Record views


Files downloads