Estimation of Reaction, Diffusion and Restitution Parameters for a 3D Myocardial Model Using Optical Mapping and MRI

Jatin Relan 1 Mihaela Pop 2 Hervé Delingette 1, * Graham Wright 2, 3 Nicholas Ayache 1, * Maxime Sermesant 1, *
* Auteur correspondant
1 ASCLEPIOS - Analysis and Simulation of Biomedical Images
CRISAM - Inria Sophia Antipolis - Méditerranée
2 Imaging Research [Sunnybrook]
3 MBP - Department of Medical Biophysics
Abstract : Personalisation, i.e. parameter estimation of a cardiac ElectroPhysiology (EP) model is needed to build patient-specific models, which could then be used to understand the true complex dynamics involved in patient's pathology. In this paper, we present a personalisation method for a simplified ionic 3D EP model, the Mitchell-Schaeffer model. The personalisation is performed by optimising the 3D model parameters, which represent the tissue conductivity, Action Potential Duration (APD) and restitution for APD and conduction velocity, using only 2D epicardial surface data obtained ex-vivo from optical imaging of large porcine healthy hearts. We are also able to estimate all of the model parameters, thus resulting in a total heart-specific 3D EP model. Finally, we also test the sensitivity of the described personalisation results with respect to different pacing locations.
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Communication dans un congrès
Oscar Camara and Mihaela Pop and Kawal Rhode and Maxime Sermesant and Nic Smith and Alistair Young. MICCAI Workshop on Statistical Atlases and Computational Models of the Heart: Mapping Structure and Function (STACOM) and a Cardiac Electrophysiological Simulation Challenge (CESC'10), 2010, Beijing, China. Springer, 6364, pp.270-280, 2010, Lecture Notes in Computer Science. 〈10.1007/978-3-642-15835-3_28〉
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Jatin Relan, Mihaela Pop, Hervé Delingette, Graham Wright, Nicholas Ayache, et al.. Estimation of Reaction, Diffusion and Restitution Parameters for a 3D Myocardial Model Using Optical Mapping and MRI. Oscar Camara and Mihaela Pop and Kawal Rhode and Maxime Sermesant and Nic Smith and Alistair Young. MICCAI Workshop on Statistical Atlases and Computational Models of the Heart: Mapping Structure and Function (STACOM) and a Cardiac Electrophysiological Simulation Challenge (CESC'10), 2010, Beijing, China. Springer, 6364, pp.270-280, 2010, Lecture Notes in Computer Science. 〈10.1007/978-3-642-15835-3_28〉. 〈inria-00616151〉

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