Estimation of Reaction, Diffusion and Restitution Parameters for a 3D Myocardial Model Using Optical Mapping and MRI

Abstract : Personalisation, i.e. parameter estimation of a cardiac ElectroPhysiology (EP) model is needed to build patient-specific models, which could then be used to understand the true complex dynamics involved in patient's pathology. In this paper, we present a personalisation method for a simplified ionic 3D EP model, the Mitchell-Schaeffer model. The personalisation is performed by optimising the 3D model parameters, which represent the tissue conductivity, Action Potential Duration (APD) and restitution for APD and conduction velocity, using only 2D epicardial surface data obtained ex-vivo from optical imaging of large porcine healthy hearts. We are also able to estimate all of the model parameters, thus resulting in a total heart-specific 3D EP model. Finally, we also test the sensitivity of the described personalisation results with respect to different pacing locations.
Type de document :
Communication dans un congrès
Oscar Camara and Mihaela Pop and Kawal Rhode and Maxime Sermesant and Nic Smith and Alistair Young. MICCAI Workshop on Statistical Atlases and Computational Models of the Heart: Mapping Structure and Function (STACOM) and a Cardiac Electrophysiological Simulation Challenge (CESC'10), 2010, Beijing, China. Springer, 6364, pp.270-280, 2010, Lecture Notes in Computer Science. 〈10.1007/978-3-642-15835-3_28〉
Liste complète des métadonnées

Littérature citée [11 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/inria-00616151
Contributeur : Project-Team Asclepios <>
Soumis le : lundi 8 juillet 2013 - 17:25:51
Dernière modification le : mercredi 30 mai 2018 - 13:56:03
Document(s) archivé(s) le : mercredi 9 octobre 2013 - 03:45:52

Fichier

relan_STACOM_MICCAI_2010.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Jatin Relan, Mihaela Pop, Hervé Delingette, Graham Wright, Nicholas Ayache, et al.. Estimation of Reaction, Diffusion and Restitution Parameters for a 3D Myocardial Model Using Optical Mapping and MRI. Oscar Camara and Mihaela Pop and Kawal Rhode and Maxime Sermesant and Nic Smith and Alistair Young. MICCAI Workshop on Statistical Atlases and Computational Models of the Heart: Mapping Structure and Function (STACOM) and a Cardiac Electrophysiological Simulation Challenge (CESC'10), 2010, Beijing, China. Springer, 6364, pp.270-280, 2010, Lecture Notes in Computer Science. 〈10.1007/978-3-642-15835-3_28〉. 〈inria-00616151〉

Partager

Métriques

Consultations de la notice

306

Téléchargements de fichiers

123