Patient-specific biomechanical simulation for deep brain stimulation

Alexandre Bilger 1
1 SHACRA - Simulation in Healthcare using Computer Research Advances
LIFL - Laboratoire d'Informatique Fondamentale de Lille, Inria Lille - Nord Europe, Inria Nancy - Grand Est
Abstract : Deep brain stimulation is a neurosurgical treatment involving the permanent implantation of electrodes in the brain, to stimulate a specific deep structure. Electrical stimulation of some brain structures treats symptoms of motor or affective neurological disorders. The success of the operation relies on the electrode placement precision, which the goal is to maximize the therapeutic outcomes, and minimize the adverse effects. To do that, a pre-operative planning step determine the target coordinates to stimulate, as well as the electrode trajectory to reach it, thanks to a combination of medical images of the patient and numerical tools. However, intra-operative brain deformation, called brain shift, might invalidate the planning. The contributions of this thesis rely on a biomechanical model of brain shift which comprises a mechanical model for deformation, as well as a model of cerebrospinal fluid leak. We present a pre-operative tool, based on our model, in order to provide to the surgeon an information on the deformation risks, that he could use to select a safe trajectory for the patient, even in the case of brain shift. Moreover, we propose an intra-operative registration method based on our biomechanical model, in order to compute the new location of anatomical structures. Finally, thanks to a model of insertion of the electrode and its interaction with brain tissue, we reproduce the operating protocol in order to compute the electrode curvature due to brain shift.
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Submitted on : Friday, December 19, 2014 - 5:07:27 PM
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Alexandre Bilger. Patient-specific biomechanical simulation for deep brain stimulation. Modeling and Simulation. Université des Sciences et Technologie de Lille, 2014. English. ⟨tel-01097488⟩

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