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K. C. Gray, D. S. Palacios, I. Dailey, M. M. Endo, B. E. Uno et al.,

, Amphotericin primarily kills yeast by simply binding ergosterol, Proceedings of the National Academy of Sciences of the United States of America, vol.109, issue.7, pp.2234-2243, 2012.

A. L. Silva, G. Ponchel, and E. Estd, Pharmaceutical strategies for amphotericin B delivery, 2017.

A. L. Silva, M. Chéron, G. Ponchel, and E. Estd, Amphotericin B-containing sodium deoxycholate micellar systems: a comparison of physicochemical characteristics of marketed products, 2017.

B. L. Burgess, Y. M. He, M. M. Baker, B. Luo, S. F. Carroll et al., NanoDisk containing super aggregated amphotericin B: a high therapeutic index antifungal formulation with enhanced potency, International Journal of Nanomedicine, vol.8, pp.4733-4775, 2013.

Q. Zia, O. Mohammad, M. A. Rauf, W. Khan, and Z. S. Biomimetically,

, Amphotericin B nano-aggregates circumvent toxicity constraints and treat systemic fungal infection in experimental animals, Scientific Reports, vol.7, 2017.

A. L. Silva, C. Aystd, M. Chéron, G. Ponchel, and E. Estd, Amphotericin B super-aggregates: formation and influence on the drug stability, 2017.

H. R. Marcelino, J. Coty, A. L. Silva, M. Chéron, C. Vauthier et al.,

, Alternative mechanism for amphotericin B uptake by macrophage cell-like: the possible role of the complement immune system, 2016.

A. L. Silva, AmB loading into micro-and nano-emulsion systems. Unpublished work, p.175, 2017.

S. Wlld, B. Damasceno, L. F. Ferreira, I. Ribeiro, K. S. Silva et al., Development and characterization of a microemulsion system containing amphotericin B with potential ocular applications, Current Drug Delivery, vol.13, issue.6, pp.982-93, 2016.

M. Ardv, A. L. Silva, S. Cojean, K. Balaraman, C. Bories et al., In vitro and in vivo antileishmanial activity of cheap amphotericin B formulations: heated amphotericin B and amphotericin B-loaded microemulsion, 2017.

A. L. Silva, Microemulsion encapsulation of an AmB soluble derivative

A. L. Silva, E. S. Egito, and G. Ponchel, Emulsion systems as a carrier for oral delivery of amphotericin B, 14èmes Journées de l'École Doctorale Innovation Thérapeutiquque, 2014.

A. L. Silva, E. S. Egito, and G. Ponchel, Evaluation of the aggregation state of amphotericin B loaded in nanoemulsions intended for oral delivery, Therapeutic Possibilities, technological ChallengesAbstract Book, pp.314-316, 2014.

A. R. Morais, A. L. Silva, K. Balaraman, N. Huang, M. Chéron et al., New formulations of amphotericin B to improve its therapeutic index for leishmaniasis treatment, COST Action CM1307 2nd Conference, p.27, 2015.

A. L. Silva, J. Genre, G. Ponchel, and E. S. Egito, Incorporação de anfotericina B em um sistema emulsionado: influência da concentração do fármaco em seu estado de agregação, XVII Congresso Científico e XVI Mostra de Extensão da

, Construção do Futuro. Natal, 2015.

A. L. Silva, J. Genre, G. Ponchel, and E. S. Egito, Nanossistema de anfotericina B para via oral: avaliação do estado de agregação do fármaco em meios siimulados, XVII Congresso Científico e XVI Mostra de Extensão da UnP, 2015.

A. L. Silva, M. Chéron, G. Ponchel, and E. S. Egito, Stability evaluation of Amphotericin B-containing micellar systems after heating process, 76th International Congress of FIP, 2016.

A. L. Silva, M. Chéron, G. Ponchel, and E. S. Egito, Is a liposomal system able to form amphotericin B super-aggregates, 11th International Congress, vol.178

, Ribeirão Preto. Pharmaceutical sciences in an emerging economy: Challenges for a sustainable world, 2017.

, D studies, my mentor and I presented to the RENORBIO a project in biotechnology entitled "Cationic nanoemulsions for gene delivery: intracellular process and in vitro/in vivo evaluation of gene expression", a natural continuation of the work developed for my master degree, in which we have developed a cationic system able to pack a plasmid DNA, clarifying the physical factors influencing the genetic material compaction into a pharmaceutical system, Stearylamine-containing cationic nanoemulsions as a promising carrier for gene delivery In 2013, when I have started my Ph

. Sud, Although in a short period of time (around four months), summed to some results from the master period, the previous Ph.D project resulted in paper entitled "Stearylamine-Containing Cationic Nanoemulsion as a Promising Carrier to Gene Delivery

, Short Curriculum vitae 182 PERSONAL INFORMATION Name: André Leandro Silva Date birth, pp.14-23

S. At, . Vicente, and . Brazil, Address: Rua 21 de Setembro, p.41

R. Gonçalves, . Barreiras, and . Bahia--brazil, , vol.47, pp.806-810

, andre_leandro@outlook.com.br or andre.leandro@ufob.edu.br FORMAL EDUCATION 2006 -2010 Bachelor in Pharmacy Universidade Potiguar

, Scholarship: Programa Universidade para Todos (ProUni), pp.2011-2013

. Msc, Capes 2013 -2017 PhD in Biotechnology / Biopharmacie et Pharmacotechnie

, Recanto dos Pássaros. UFOB -Campus Reitor Edgard Santos Centro das Ciências Biológicas e da Saúde Curso, vol.316, 2017.

. Phd,

, PhD Student

D. Nobre, , 2010.

, Pague Menos Drugstore 2010 -2013 Pharmacist LANGUAGE SKILLS 1. Portuguese: Native 2. Spanish: Fluent 3. French: Advanced 4. English: Advanced LIST OF PUBLICATIONS

A. Silva, . Marcelino, . Hr;-veríssimo, . Lm;-araújo, . Ib;-agnez-lima et al., Stearylamine-containing cationic nanoemulsion as a promising carrier for gene delivery, Journal of Nanoscience and Nanotechnology (Print), vol.16, pp.1339-1384, 2016.

W. L. Silveira and B. P. Damasceno,

. Ferreira, . Lf;-ribeiro, K. Il;-silva, and A. ;. Silva,

M. Giannini, . Silva-júnior, A. ;. Aa;-oliveira, and E. Egito, Development and characterization of a microemulsion system containing amphotericin B with potential ocular applications, Current Drug Delivery, vol.13, issue.6, pp.982-93, 2016.

A. Silva, . Veríssimo, . Lm;-agnez-lima, and L. Lf;-egito,

A. ;. Oliveira and E. Egito, Physical factors affecting plasmid DNA compaction in stearylamine-containing nanoemulsions intended for gene delivery, Pharmaceuticals, vol.5, pp.643-54, 2012.

A. Silva, T. Fernandes, . Silva, and L. D. Ks;-pires, Comparação dos métodos hospitalar e domiciliar de fracionamento de comprimidos de Furosemida 40mg, Catussaba, vol.1, pp.31-40, 2011.

, The full CV can be