R. Adolphs, The Biology of Fear, Current Biology, vol.23, issue.2, pp.79-93, 2013.

,

A. D. Albers, J. Asafu-adjei, M. K. Delaney, K. E. Kelly, T. Gomez-isla et al., Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly: POEM: Odor Memory Biomarker in Normal Elderly, Annals of Neurology, vol.80, issue.6, pp.846-857, 2016.

,

G. M. Alexander, S. C. Rogan, A. I. Abbas, B. N. Armbruster, Y. Pei et al., Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors, Neuron, vol.63, issue.1, pp.27-39, 2009.

S. G. Anagnostaras, S. Maren, J. R. Sage, S. Goodrich, and M. S. Fanselow, Scopolamine and Pavlovian fear conditioning in rats: dose-effect analysis, Neuropsychopharmacology, vol.21, issue.6, pp.731-744, 1999.

A. Apicella, Q. Yuan, M. Scanziani, and J. S. Isaacson, Pyramidal Cells in Piriform Cortex Receive Convergent Input from Distinct Olfactory Bulb Glomeruli, Journal of Neuroscience, vol.30, issue.42, pp.14255-14260, 2010.

B. N. Armbruster, X. Li, M. H. Pausch, S. Herlitze, and B. L. Roth, Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand, Proceedings of the National Academy of Sciences, vol.104, issue.12, pp.5163-5168, 2007.

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar et al., Glial and neuronal control of brain blood flow, Nature, vol.468, issue.7321, pp.232-243, 2010.

B. Auffarth, Understanding smell-The olfactory stimulus problem, Neuroscience & Biobehavioral Reviews, vol.37, issue.8, pp.1667-1679, 2013.

K. R. Bailey and J. N. Crawley, Anxiety-Related Behaviors in Mice, Methods of Behavior Analysis in Neuroscience, 2009.

S. A. Barnett, The Rat. A study in behavior New Brunswick and London: Aldine Transaction, 2009.

D. C. Barnes, J. Chapuis, D. Chaudhury, and D. A. Wilson, Odor Fear Conditioning Modifies Piriform Cortex Local Field Potentials Both during Conditioning and during PostConditioning Sleep, PLoS ONE, vol.6, issue.3, 2011.

J. M. Bekkers and N. Suzuki, Neurons and circuits for odor processing in the piriform cortex, Trends in Neurosciences, vol.36, issue.7, pp.429-438, 2013.

A. Ben-yakov, Y. Dudai, and M. R. Mayford, Memory Retrieval in Mice and Men. Cold Spring Harbor Perspectives in Biology, 2015.

H. T. Blair, Synaptic Plasticity in the Lateral Amygdala: A Cellular Hypothesis of Fear Conditioning, Learning & Memory, vol.8, issue.5, pp.229-242, 2001.

H. C. Bergstrom, The neurocircuitry of remote cued fear memory, Neuroscience & Biobehavioral Reviews, vol.71, pp.409-417, 2016.

T. V. Bliss and T. Lømo, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, The Journal of Physiology, vol.232, issue.2, pp.331-356, 1973.

K. A. Bolding and K. M. Franks, Complementary codes for odor identity and intensity in olfactory cortex. eLife, vol.6, 2017.

S. Bouret and S. J. Sara, Locus coeruleus activation modulates firing rate and temporal organization of odour-induced single-cell responses in rat piriform cortex, Eur. J. Neurosci, vol.16, pp.2371-2382, 2002.

T. Branco and K. Staras, The probability of neurotransmitter release: variability and feedback control at single synapses, Nature Reviews. Neuroscience, vol.10, issue.5, p.373, 2009.

J. Chapuis and D. A. Wilson, Bidirectional plasticity of cortical pattern recognition and behavioral sensory acuity, Nature Neuroscience, vol.15, issue.1, pp.155-161, 2011.

J. Chapuis and D. A. Wilson, Cholinergic modulation of olfactory pattern separation, Neuroscience Letters, vol.545, pp.50-53, 2013.

J. Chapuis, Y. Cohen, X. He, Z. Zhang, S. Jin et al., Lateral Entorhinal Modulation of Piriform Cortical Activity and Fine Odor Discrimination, Journal of Neuroscience, vol.33, issue.33, pp.13449-13459, 2013.

C. F. Chen, D. C. Barnes, and D. A. Wilson, Generalized vs. stimulus-specific learned fear differentially modifies stimulus encoding in primary sensory cortex of awake rats, Journal of Neurophysiology, vol.106, issue.6, pp.3136-3144, 2011.

. Chen, F. Chien-fu, D. Zou, C. G. Altomare, L. Xu et al., , 2014.

, Nonsensory target-dependent organization of piriform cortex, Proceedings of the National Academy of Sciences, vol.111, pp.16931-16936

G. B. Choi, D. D. Stettler, B. R. Kallman, S. T. Bhaskar, A. Fleischmann et al., , 2011.

, Driving Opposing Behaviors with Ensembles of Piriform Neurons, Cell, vol.146, issue.6, pp.1004-1015

,

S. Chu and J. J. Downes, Odour-evoked autobiographical memories: psychological investigations of Proustian phenomena, Chem. Senses, vol.25, pp.111-116, 2000.

A. J. Cole, D. W. Saffen, . Baraban, and P. F. Worley, Rapid increase of an immediate-early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation, Nature, vol.340, pp.474-476, 1989.

C. Counet, D. Callemien, C. Ouwerx, and S. Collin, Use of Gas ChromatographyOlfactometry To Identify Key Odorant Compounds in Dark Chocolate. Comparison of Samples before and after Conching, Journal of Agricultural and Food Chemistry, vol.50, issue.8, pp.2385-2391, 2002.

K. K. Cowansage, T. Shuman, B. C. Dillingham, A. Chang, P. Golshani et al., , 2014.

, Direct Reactivation of a Coherent Neocortical Memory of Context, Neuron, vol.84, issue.2, pp.432-441

,

T. Curran and I. M. Verma, FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product, Virology, vol.135, pp.218-228, 1984.

F. Datiche and M. Cattarelli, Catecholamine innervation of the piriform cortex: a tracing and immunohistochemical study in the rat, BrainRes, vol.710, pp.69-78, 1996.

F. Datiche, F. Roullet, and M. Cattarelli, Expression of Fos in the piriform cortex after acquisition of olfactory learning: an immunohistochemical study in the rat, Brain Research Bulletin, vol.55, issue.1, pp.95-99, 2001.

R. L. Davis, Olfactory learning, Neuron, vol.44, issue.1, pp.31-48, 2004.

J. L. Debose and G. A. Nevitt, The use of odors at different spatial scales: comparing birds with fish, Journal of Chemical Ecology, vol.34, issue.7, pp.867-881, 2008.

E. De-rosa and M. E. Hasselmo, Muscarinic cholinergic neuromodulation reduces proactive interference between stored odor memories during associative learning in rats, Behavioral Neuroscience, vol.114, issue.1, pp.32-41, 2000.

K. Deisseroth, Optogenetics. Nature Methods, vol.8, issue.1, pp.26-29, 2011.

C. A. Denny, M. A. Kheirbek, E. L. Alba, K. F. Tanaka, R. A. Brachman et al., Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis, Neuron, vol.83, issue.1, pp.189-201, 2014.

A. Diodato, M. Ruinart-de-brimont, Y. S. Yim, N. Derian, S. Perrin et al., Molecular signatures of neural connectivity in the olfactory cortex, Nature Communications, vol.7, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01360100

S. Dong, J. A. Allen, M. Farrell, and B. L. Roth, A chemical-genetic approach for precise spatio-temporal control of cellular signaling, Molecular BioSystems, vol.6, issue.8, p.1376, 2010.

R. Dragunow-m-et-faull, The use of c-fos as a metabolic marker in neuronal pathway tracing, J Neurosci Methods, vol.29, pp.261-265, 1989.

Y. Dudai, A. Karni, and J. Born, The Consolidation and Transformation of Memory, Neuron, vol.88, issue.1, pp.20-32, 2015.

S. M. Dudek and M. F. Bear, Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus, Journal of Neuroscience, vol.13, issue.7, pp.2910-2918, 1993.

H. Eichenbaum, A cortical-hippocampal system for declarative memory, Nature Reviews. Neuroscience, vol.1, issue.1, p.41, 2000.

J. P. Fadok, T. M. Dickerson, and R. D. Palmiter, Dopamine Is Necessary for CueDependent Fear Conditioning, Journal of Neuroscience, vol.29, issue.36, pp.11089-11097, 2009.

S. M. Ferguson, D. Eskenazi, M. Ishikawa, M. J. Wanat, P. E. Phillips et al.,

J. F. Neumaier, Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization, Nature Neuroscience, vol.14, issue.1, pp.22-24, 2011.

R. D. Fields, F. Eshete, B. Stevens, and K. Itoh, Action potential-dependent regulation of gene expression: temporal specificity in Ca2+, cAMP-responsive element binding proteins, and mitogen-activated protein kinase signaling, Journal of Neuroscience, vol.17, issue.19, pp.7252-7266, 1997.

A. Fleischmann, O. Hvalby, V. Jensen, T. Strekalova, C. Zacher et al., Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS, Journal of Neuroscience, vol.23, issue.27, pp.9116-9122, 2003.

M. L. Fletcher, Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses. Frontiers in Systems Neuroscience, 2012.

K. M. Franks, M. J. Russo, D. L. Sosulski, A. A. Mulligan, S. A. Siegelbaum et al., Recurrent Circuitry Dynamically Shapes the Activation of Piriform Cortex, Neuron, vol.72, issue.1, pp.49-56, 2011.

G. D. Gale, Role of the Basolateral Amygdala in the Storage of Fear Memories across the Adult Lifetime of Rats, Journal of Neuroscience, vol.24, issue.15, pp.3810-3815, 2004.

/. Jneurosci, , pp.4100-4103, 2004.

G. D. Gale, S. G. Anagnostaras, and M. S. Fanselow, Cholinergic modulation of pavlovian fear conditioning: effects of intrahippocampal scopolamine infusion, Hippocampus, vol.11, issue.4, pp.371-376, 2001.

A. R. Garner, D. C. Rowland, S. Y. Hwang, K. Baumgaertel, B. L. Roth et al., Generation of a Synthetic Memory Trace, Science, vol.335, issue.6075, pp.1513-1516, 2012.

,

A. Gdalyahu, E. Tring, P. Polack, R. Gruver, P. Golshani et al., Associative Fear Learning Enhances Sparse Network Coding in Primary Sensory Cortex, Neuron, vol.75, issue.1, pp.121-132, 2012.

R. L. Gellman and G. K. Aghajanian, Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons, BrainRes, vol.600, pp.63-73, 1993.

S. Ghosh, S. D. Larson, H. Hefzi, Z. Marnoy, T. Cutforth et al., , 2011.

, Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons, Nature, issue.7342, pp.217-220

A. J. Giessel and S. R. Datta, Olfactory maps, circuits and computations, Current Opinion in Neurobiology, vol.24, pp.120-132, 2014.

F. Gore, E. C. Schwartz, B. C. Brangers, S. Aladi, J. M. Stujenske et al.,

R. Axel, Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses, Cell, vol.162, issue.1, pp.134-145, 2015.

I. Goshen, M. Brodsky, R. Prakash, J. Wallace, V. Gradinaru et al., Dynamics of Retrieval Strategies for Remote Memories, Cell, vol.147, issue.3, pp.678-689, 2011.

,

J. A. Gottfried, Central mechanisms of odour object perception, Nature Reviews Neuroscience, vol.11, issue.9, pp.628-641, 2010.

H. C. Gourdon and A. A. Lagrutta, The primate hippocampal formation: evidence for a time-limited role in memory storage, Biochim. Biophys. Acta, p.84, 1988.

B. F. Grewe, J. Gründemann, L. J. Kitch, J. A. Lecoq, J. G. Parker et al.,

M. J. Schnitzer, Neural ensemble dynamics underlying a long-term associative memory, Nature, vol.543, issue.7647, pp.670-675, 2017.

C. J. Guenthner, K. Miyamichi, H. H. Yang, H. C. Heller, and L. Luo, Permanent Genetic Access to Transiently Active Neurons via TRAP: Targeted Recombination in Active Populations, Neuron, vol.78, issue.5, pp.773-784, 2013.

J. F. Guzowski, Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches, Hippocampus, vol.12, issue.1, pp.86-104, 2002.

J. F. Guzowski, J. A. Timlin, B. Roysam, B. L. Mcnaughton, P. F. Worley et al., Mapping behaviorally relevant neural circuits with immediate-early gene expression. Current Opinion in Neurobiology, vol.15, pp.599-606, 2005.

L. B. Haberly, Neuronal circuitry in olfactory cortex: anatomy and functional implications, Chem Senses, vol.10, pp.219-238, 1985.

L. B. Haberly, Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitry, Chem Senses, vol.26, pp.551-576, 2001.

A. Hagiwara, S. K. Pal, T. F. Sato, M. Wienisch, and V. N. Murthy, Optophysiological analysis of associational circuits in the olfactory cortex, Frontiers in Neural Circuits, 2012.

B. S. Hansson and M. C. Stensmyr, Evolution of Insect Olfaction, Neuron, vol.72, issue.5, pp.698-711, 2011.

J. A. Harris, Using c-fos as a neural marker of pain, Brain Research Bulletin, vol.45, issue.1, pp.1-8, 1998.

M. E. Hasselmo and E. Barkai, Cholinergic modulation of activity-dependent synaptic plasticity in the piriform cortex and associative memory function in a network biophysical simulation, Journal of Neuroscience, vol.15, issue.10, pp.6592-6604, 1995.

M. E. Hasselmo, C. Linster, M. Patil, D. Ma, and M. Cekic, Noradrenergic suppression of synaptic transmission may influence cortical signal-to-noise ratio, Journal of Neurophysiology, vol.77, issue.6, pp.3326-3339, 1997.

D. O. Hebb, The Organization of Behavior: A Neuropsychological Theory, 1949.

J. D. Herdegen-t-et-leah, Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins, Brain Res Brain Res Rev, vol.28, pp.370-490, 1998.

D. G. Herrera and H. A. Robertson, Activation of c-fos in the brain, Progress in Neurobiology, vol.50, issue.2-3, pp.83-107, 1996.

C. Herry and J. P. Johansen, Encoding of fear learning and memory in distributed neuronal circuits, Nature Neuroscience, vol.17, issue.12, pp.1644-1654, 2014.

K. R. Illig and L. B. Haberly, Odor-evoked activity is spatially distributed in piriform cortex, The Journal of Comparative Neurology, vol.457, issue.4, pp.361-373, 2003.

L. Jiang, S. Kundu, J. D. Lederman, G. Y. López-hernández, E. C. Ballinger et al.,

L. W. Role, Cholinergic Signaling Controls Conditioned Fear Behaviors and Enhances Plasticity of Cortical-Amygdala Circuits, Neuron, vol.90, issue.5, pp.1057-1070, 2016.

,

J. P. Johansen, L. Diaz-mataix, H. Hamanaka, T. Ozawa, E. Ycu et al., Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation, Proceedings of the National Academy of Sciences, vol.111, issue.51, pp.5584-5592, 2014.

F. W. Johenning, P. S. Beed, T. Trimbuch, M. H. Bendels, J. Winterer et al.,

, Dendritic Compartment and Neuronal Output Mode Determine Pathway-Specific LongTerm Potentiation in the Piriform Cortex, Journal of Neuroscience, vol.29, issue.43, pp.13649-13661

D. M. Johnson, K. R. Illig, M. Behan, and L. B. Haberly, New features of connectivity in piriform cortex visualized by intracellular injection of pyramidal cells suggest that "primary" olfactory cortex functions like "association" cortex in other sensory systems, Journal of Neuroscience, vol.20, issue.18, pp.6974-6982, 2000.

S. V. Jones, D. C. Choi, M. Davis, and K. J. Ressler, Learning-Dependent Structural Plasticity in the Adult Olfactory Pathway, Journal of Neuroscience, vol.28, issue.49, pp.13106-13111, 2008.

J. Huang, Z. Zeng, and H. , Genetic Approaches to Neural Circuits in the Mouse, Annual Review of Neuroscience, vol.36, issue.1, pp.183-215, 2013.

,

S. A. Josselyn, S. Köhler, and P. W. Frankland, Finding the engram, Nature Reviews Neuroscience, vol.16, issue.9, pp.521-534, 2015.

E. R. Kandel and L. Tauc, Mechanism of prolonged heterosynaptic facilitation, Nature, p.145, 1964.

E. D. Kanter and L. B. Haberly, Associative long-term potentiation in piriform cortex slices requires GABAA blockade, Journal of Neuroscience, vol.13, issue.6, pp.2477-2482, 1993.

E. D. Kanter and L. B. Haberly, NMDA-dependent induction of long-term potentiation in afferent and association fiber systems of piriform cortex in vitro, Brain Res, vol.525, pp.175-179, 1990.

M. D. Kass, M. C. Rosenthal, J. Pottackal, and J. P. Mcgann, Fear learning enhances neural responses to threat-predictive stimuli, Science, vol.342, pp.1389-92, 2013.

H. K. Kato, M. W. Chu, J. S. Isaacson, and T. Komiyama, Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience, Neuron, vol.76, pp.962-75, 2012.

U. B. Kaupp, Olfactory signalling in vertebrates and insects: differences and commonalities, Nature Reviews Neuroscience, 2010.

C. G. Kentros, N. T. Agnihotri, S. Streater, R. D. Hawkins, and E. R. Kandel, Increased attention to spatial context increases both place field stability and spatial memory, Neuron, vol.42, issue.2, pp.283-295, 2004.

J. J. Kim and M. S. Fanselow, Modality-specific retrograde amnesia of fear, Science, vol.256, issue.5057, pp.675-677, 1992.

T. Kitamura, S. K. Ogawa, D. S. Roy, T. Okuyama, M. D. Morrissey et al., Engrams and circuits crucial for systems consolidation of a memory, Science, vol.356, issue.6333, pp.73-78, 2017.

K. Kobayakawa, R. Kobayakawa, H. Matsumoto, Y. Oka, T. Imai et al., Innate versus learned odour processing in the mouse olfactory bulb, Nature, vol.450, issue.7169, pp.503-508, 2007.

K. J. Kovacs, c-Fos as a transcription factor: a stressful (re)view from a functional map, Neurochem Int, vol.33, pp.287-297, 1998.

M. J. Krashes, S. Koda, C. Ye, S. C. Rogan, A. C. Adams et al.,

B. B. Lowell, Rapid, reversible activation of AgRP neurons drives feeding behavior in mice, Journal of Clinical Investigation, vol.121, issue.4, pp.1424-1428, 2011.

J. E. Krettek and J. L. Price, Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat, J. Comp. Neurol, vol.178, pp.225-254, 1978.

M. Larsson and J. Willander, Autobiographical odor memory, Annals of the New York Academy of Sciences, vol.1170, pp.318-323, 2009.

K. S. Lashley, Brain Mechanisms and Intelligence. A Quantitative Study of Injuries to the Brain, 1929.

J. E. Ledoux, Emotion, memory and the brain, Scientific American, vol.7, issue.1, pp.68-75, 1997.

J. J. Letzkus, S. B. Wolff, E. M. Meyer, P. Tovote, J. Courtin et al., A disinhibitory microcircuit for associative fear learning in the auditory cortex, Nature, vol.480, issue.7377, pp.331-335, 2011.

W. Li, J. D. Howard, and J. A. Gottfried, Disruption of odour quality coding in piriform cortex mediates olfactory deficits in Alzheimer's disease, Brain, vol.133, issue.9, pp.2714-2726, 2010.

W. Li, J. D. Howard, T. B. Parrish, and J. A. Gottfried, Aversive Learning Enhances Perceptual and Cortical Discrimination of Indiscriminable Odor Cues, Science, issue.5871, pp.1842-1845, 2008.

,

P. Litaudon, A. Mouly, R. Sullivan, R. Gervais, and M. Cattarelli, Learning-induced changes in rat piriform cortex activity mapped using multisite recording with voltage sensitive dye, European Journal of Neuroscience, vol.9, issue.8, pp.1593-1602, 1997.
URL : https://hal.archives-ouvertes.fr/hal-02284775

X. Liu, S. Ramirez, P. T. Pang, C. B. Puryear, A. Govindarajan et al., Optogenetic stimulation of a hippocampal engram activates fear memory recall, 2012.

M. Lovett-barron, P. Kaifosh, M. A. Kheirbek, N. Danielson, J. D. Zaremba et al., Dendritic Inhibition in the, Hippocampus Supports Fear Learning. Science, vol.343, issue.6173, pp.857-863, 2014.

V. M. Luna and A. Morozov, Input-specific excitation of olfactory cortex microcircuits, Front. NeuralCircuits, vol.6, p.69, 2012.

H. Lütcke, D. J. Margolis, and F. Helmchen, Steady or changing? Long-term monitoring of neuronal population activity, Trends in Neurosciences, vol.36, issue.7, pp.375-384, 2013.

L. Madisen, T. A. Zwingman, S. M. Sunkin, S. W. Oh, H. A. Zariwala et al.,

H. Zeng, A robust and high-throughput Cre reporting and characterization system for the whole mouse brain, Nature Neuroscience, vol.13, issue.1, pp.133-140, 2010.

K. Majak, S. Ronkko, S. Kemppainen, and A. Pitkanen, Projections from the amygdaloid complex to the piriform cortex: a PHA-L study in the rat, J. Comp.Neurol, vol.476, pp.414-428, 2004.

N. Mandairon, F. Kermen, C. Charpentier, J. Sacquet, C. Linster et al., Contextdriven activation of odor representations in the absence of olfactory stimuli in the olfactory bulb and piriform cortex, Frontiers in Behavioral Neuroscience, 2014.

S. Maren, G. Aharonov, and M. S. Fanselow, Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient, Behav. Neurosci, vol.110, pp.718-744, 1996.

S. Maren, Synaptic Mechanisms of Associative Memory in the Amygdala, Neuron, vol.47, issue.6, pp.783-786, 2005.

H. Markram, J. Lübke, M. Frotscher, and B. Sakmann, Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs, Science, vol.275, pp.213-215, 1997.

H. Markram, A history of spike-timing-dependent plasticity, Frontiers in Synaptic Neuroscience, 2011.

D. Marr, Simple memory: a theory for archicortex, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol.262, p.2381, 1971.

S. J. Martin, P. D. Grimwood, and R. G. Morris, Synaptic plasticity and memory: an evaluation of the hypothesis, Annual Review of Neuroscience, vol.23, issue.1, pp.649-711, 2000.

S. Milanovic, J. Radulovic, O. Laban, O. Stiedl, F. Henn et al., Production of the Fos protein after contextual fear conditioning of C57BL/6N mice, Brain Research, vol.784, issue.1, pp.37-47, 1998.

K. Minatohara, M. Akiyoshi, and H. Okuno, Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace. Frontiers in Molecular Neuroscience, 2016.

K. Miura, Z. F. Mainen, and N. Uchida, Odor Representations in Olfactory Cortex: Distributed Rate Coding and Decorrelated Population Activity, Neuron, vol.74, issue.6, pp.1087-1098, 2012.

K. Miyamichi, F. Amat, F. Moussavi, C. Wang, I. Wickersham et al.,

L. Luo, , 2011.

, Cortical representations of olfactory input by trans-synaptic tracing, Nature, vol.472, issue.7342, pp.191-196

P. Mombaerts, F. Wang, C. Dulac, S. K. Chao, A. Nemes et al., Visualizing an olfactory sensory map, Cell, vol.87, pp.675-686, 1996.

K. Mori, Maps of Odorant Molecular Features in the, Mammalian Olfactory Bulb. Physiological Reviews, vol.86, issue.2, pp.409-433, 2006.

A. M. Mouly, A. Fort, N. Ben-boutayab, and R. Gervais, Olfactory learning induces differential longlasting changes in rat central olfactory pathways, Neuroscience, vol.102, pp.11-21, 2001.
URL : https://hal.archives-ouvertes.fr/hal-02284770

C. Murphy, Loss of olfactory function in dementing disease, Physiology & Behavior, vol.66, issue.2, pp.177-182, 1999.

S. Nabavi, R. Fox, C. D. Proulx, J. Y. Lin, R. Y. Tsien et al., Engineering a memory with LTD and LTP, Nature, vol.511, issue.7509, pp.348-352, 2014.

T. Otto, G. Cousens, and C. Herzog, Behavioral and neuropsychological foundations of olfactory fear conditioning, Behavioural Brain Research, vol.110, issue.1, pp.119-128, 2000.

E. Pastalkova, P. Serrano, D. Pinkhasova, E. Wallace, A. A. Fenton et al., Storage of spatial information by the maintenance mechanism of LTP, Science, issue.5790, pp.1141-1144, 2006.

M. M. Patil, C. Linster, E. Lubenov, and M. E. Hasselmo, Cholinergic agonist carbachol enables associative long-term potentiation in piriform cortex slices, Journal of Neurophysiology, vol.80, issue.5, pp.2467-2474, 1998.

E. Pavesi, A. Gooch, E. Lee, and M. L. Fletcher, Cholinergic modulation during acquisition of olfactory fear conditioning alters learning and stimulus generalization in mice, Learning and Memory, vol.20, issue.1, pp.6-10, 2012.

V. Pawlak, J. R. Wickens, A. Kirkwood, and J. N. Kerr, Timing is not everything: neuromodulation opens the STDP gate. Frontiers in Synaptic Neuroscience, 2010.

V. Pedrosa and C. Clopath, The Role of Neuromodulators in Cortical Plasticity. A Computational Perspective. Frontiers in Synaptic Neuroscience, 2017.

C. Peirs, S. G. Williams, X. Zhao, C. E. Walsh, J. Y. Gedeon et al., Dorsal Horn Circuits for Persistent Mechanical Pain, Neuron, vol.87, issue.4, pp.797-812, 2015.

,

E. A. Phelps and J. E. Ledoux, Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior, Neuron, vol.48, issue.2, pp.175-187, 2005.

R. G. Phillips and J. E. Ledoux, Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning, Behav. Neurosci, vol.106, issue.2, pp.274-285, 1992.

M. M. Pina, E. A. Young, A. E. Ryabinin, and C. L. Cunningham, The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice, Neuropharmacology, vol.99, pp.627-638, 2015.

,

J. Platenik, N. Kuramoto, and Y. Yoneda, Molecular mechanisms associated with long-term consolidation of the NMDA signals, Life Sci, vol.67, pp.335-364, 2000.

C. Poo and J. S. Isaacson, Sparse" Coding, Global Inhibition, and Oscillations, Neuron, vol.62, issue.6, pp.850-861, 2009.

C. Poo and J. S. Isaacson, A Major Role for Intracortical Circuits in the Strength and Tuning of Odor-Evoked Excitation in Olfactory Cortex, Neuron, vol.72, issue.1, pp.41-48, 2011.

M. V. Puig, J. Rose, R. Schmidt, and N. Freund, Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds. Frontiers in Neural Circuits, 2014.

J. Radulovic, J. Kammermeier, and J. Spiess, Relationship between fos production and classical fear conditioning: effects of novelty, latent inhibition, and unconditioned stimulus preexposure, Journal of Neuroscience, vol.18, issue.18, pp.7452-7461, 1998.

R. Richardson, Extinction of conditioned odor potentiation of startle, Neurobiology of Learning and Memory, vol.78, issue.2, pp.426-440, 2002.

L. Reijmers, Genetic control of active neural circuits. Frontiers in Molecular Neuroscience, vol.2, 2009.

L. G. Reijmers, B. L. Perkins, N. Matsuo, and M. Mayford, Localization of a Stable Neural Correlate of Associative Memory, Science, issue.5842, pp.1230-1233, 2007.

,

R. L. Rennaker, C. F. Chen, A. M. Ruyle, A. M. Sloan, and D. A. Wilson, Spatial and Temporal Distribution of Odorant-Evoked Activity in the Piriform Cortex, Journal of Neuroscience, vol.27, issue.7, pp.1534-1542, 2007.

K. J. Ressler, G. Paschall, X. Zhou, and M. Davis, Regulation of synaptic plasticity genes during consolidation of fear conditioning, Journal of Neuroscience, vol.22, issue.18, pp.7892-7902, 2002.

S. M. Rodrigues, G. E. Schafe, and J. E. Ledoux, Molecular mechanisms underlying emotional learning and memory in the lateral amygdala, Neuron, vol.44, issue.1, pp.75-91, 2004.

M. R. Roesch, T. A. Stalnaker, and G. Schoenbaum, Associative encoding in anterior piriform cortex versus orbitofrontal cortex during odor discrimination and reversal learning, Cereb Cortex, 2006.

B. Roland, T. Deneux, K. M. Franks, B. Bathellier, and A. Fleischmann, Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex. eLife. 6: e26337, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02062212

C. M. Root, C. A. Denny, R. Hen, and R. Axel, The participation of cortical amygdala in innate, odour-driven behaviour, Nature, vol.515, issue.7526, pp.269-273, 2014.

F. S. Roman, F. A. Chaillan, and B. Soumireu-mourat, Long-term potentiation in rat piriform cortex following discrimination learning, Brain Res, vol.601, pp.265-272, 1993.

F. S. Roman, I. Simonetto, and B. Soumireu-mourat, Learning and memory of odorreward association: selective impairment following horizontal diagonal band lesions, Behav Neurosci, vol.107, pp.72-81, 1993.

L. M. Romanski and J. E. Ledoux, Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning, Neurosci. Lett, vol.142, pp.228-232, 1992.

J. A. Rosenkranz and A. A. Grace, Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning, Nature, vol.417, pp.282-287, 2002.

T. J. Ryan, D. S. Roy, M. Pignatelli, A. Arons, and S. Tonegawa, Engram cells retain memory under retrograde amnesia, Science, vol.348, pp.1007-1013, 2015.

T. Sacco and B. Sacchetti, Role of Secondary Sensory Cortices in Emotional Memory Storage and Retrieval in Rats, Science, vol.329, issue.5992, pp.649-656, 2010.

,

B. Sadrian and D. A. Wilson, Optogenetic Stimulation of Lateral Amygdala Input to Posterior Piriform Cortex Modulates Single-Unit and Ensemble Odor Processing, Frontiers in Neural Circuits, 9, 2015.

G. Schoenbaum, Lesions of Orbitofrontal Cortex and Basolateral Amygdala Complex Disrupt Acquisition of Odor-Guided Discriminations and Reversals, Learning & Memory, vol.10, issue.2, pp.129-140, 2003.

P. Schoenenberger, D. Gerosa, and T. G. Oertner, Temporal control of immediate early gene induction by light, PloS One, vol.4, issue.12, p.8185, 2009.

R. T. Semon and . Mneme, , 1921.

A. Seoane, C. J. Tinsley, and M. W. Brown, Interfering with Fos expression in rat perirhinal cortex impairs recognition memory, Hippocampus, vol.22, issue.11, pp.2101-2113, 2012.

Y. Sevelinges, R. Gervais, B. Messaoudi, L. Granjon, and A. Mouly, Olfactory fear conditionning induces field potential potentiation in rat olfactory cortex and amygdala, Learn Mem, 2004.

A. M. Shakhawat, C. W. Harley, and Q. Yuan, Arc Visualization of Odor Objects Reveals Experience-Dependent Ensemble Sharpening, Separation, and Merging in Anterior Piriform Cortex in Adult Rat, Journal of Neuroscience, vol.34, issue.31, pp.10206-10210, 2014.

F. R. Sharp, M. F. Gonzalez, J. W. Sharp, and S. M. Sagar, c-fos expression and (14C) 2-deoxyglucose uptake in the caudal cerebellum of the rat during motor/sensory cortex stimulation, Journal of Comparative Neurology, vol.284, issue.4, pp.621-636, 1989.

M. Sheng and M. E. Greenberg, The regulation and function of c-fos and other immediate early genes in the nervous system, Neuron, vol.4, pp.477-485, 1990.

P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser, Dendritic Excitability and Synaptic Plasticity, Physiological Reviews, vol.88, issue.2, pp.769-840, 2008.

B. Slotnick, Animal cognition and the rat olfactory system, Trends in Cognitive Sciences, vol.5, issue.5, pp.216-222, 2001.

D. L. Sosulski, M. Bloom, T. Cutforth, R. Axel, and S. R. Datta, Distinct representations of olfactory information in different cortical centres, Nature, issue.7342, pp.213-216, 2011.

L. R. Squire, Memory systems of the brain: A brief history and current perspective, Neurobiology of Learning and Memory, vol.82, issue.3, pp.171-177, 2004.

L. R. Squire, The Legacy of Patient H.M. for Neuroscience, pp.6-9, 2009.

,

U. Staubli, F. Schottler, and D. Nejat-bina, Role of dorsomedial thalamic nucleus and piriform cortex in processing olfactory information, Behav Brain Res, vol.25, pp.117-129, 1987.

T. Stefanelli, C. Bertollini, C. Lüscher, D. Muller, and P. Mendez, Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles, Neuron, vol.89, issue.5, pp.1074-1085, 2016.

,

D. D. Stettler and R. Axel, Representations of Odor in the Piriform Cortex, Neuron, vol.63, issue.6, pp.854-864, 2009.

N. Suzuki and J. M. Bekkers, Inhibitory neurons in the anterior piriform cortex of the mouse: Classification using molecular markers, The Journal of Comparative Neurology, vol.518, issue.10, pp.1670-1687, 2010.

N. Suzuki and J. M. Bekkers, Microcircuits Mediating Feedforward and Feedback Synaptic Inhibition in the Piriform Cortex, Journal of Neuroscience, vol.32, issue.3, pp.919-931, 2012.

T. Takeuchi, A. J. Duszkiewicz, and R. G. Morris, The synaptic plasticity and memory hypothesis: encoding, storage and persistence, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.369, pp.20130288-20130288, 1633.

K. Z. Tanaka, A. Pevzner, A. B. Hamidi, Y. Nakazawa, J. Graham et al., , 2014.

, Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval, Neuron, vol.84, issue.2, pp.347-354

K. K. Tayler, K. Z. Tanaka, L. G. Reijmers, and B. J. Wiltgen, Reactivation of Neural Ensembles during the Retrieval of Recent and Remote Memory, Current Biology, vol.23, issue.2, pp.99-106, 2013.

,

W. Tischmeyer and R. Grimm, Activation of immediate early genes and memory formation, Cell Mol Life Sci, vol.55, pp.564-574, 1999.

S. Tonegawa, X. Liu, S. Ramirez, and R. Redondo, Memory Engram Cells Have Come of Age, Neuron, vol.87, issue.5, pp.918-931, 2015.

A. G. Varga and D. W. Wesson, Distributed auditory sensory input within the mouse olfactory cortex, European Journal of Neuroscience, vol.37, issue.4, pp.564-571, 2013.

E. Vermetten and J. D. Bremner, Olfaction as a traumatic reminder in posttraumatic stress disorder: case reports and review, J Clin Psychiatry, vol.64, pp.202-209, 2003.

M. E. Wang, E. G. Wann, R. K. Yuan, M. M. Ramos-alvarez, S. M. Stead et al., Long-Term Stabilization of Place Cell Remapping Produced by a Fearful Experience, Journal of Neuroscience, vol.32, issue.45, pp.15802-15814, 2012.

N. M. Weinberger, Dynamic Regulation of Receptive Fields and Maps in the Adult Sensory Cortex, Annual Review of Neuroscience, vol.18, issue.1, pp.129-158, 1995.

N. M. Weinberger, Specific long-term memory traces in primary auditory cortex, Nature Reviews Neuroscience, vol.5, issue.4, pp.279-290, 2004.

D. A. Wilson and R. J. Stevenson, The fundamental role of memory in olfactory perception, Trends in Neurosciences, vol.26, issue.5, pp.243-247, 2003.

D. A. Wilson, Pattern Separation and Completion in Olfaction, Annals of the New York Academy of Sciences, vol.1170, issue.1, pp.306-312, 2009.

,

M. P. Witter, H. J. Groenewegen, F. H. Lopes-da-silva, and A. H. Lohman, Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region, Prog. Neurobiol, vol.33, pp.161-253, 1989.

P. Wulff and B. R. Arenkiel, Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity, Current Opinion in Neurobiology, vol.22, issue.1, pp.54-60, 2012.

C. Zhan and M. Luo, Diverse Patterns of Odor Representation by Neurons in the Anterior Piriform Cortex of Awake Mice, Journal of Neuroscience, vol.30, issue.49, pp.16662-16672, 2010.

C. Zhan, J. Zhou, Q. Feng, J. Zhang, S. Lin et al., Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively. Journal of Neuroscience, vol.33, issue.8, pp.3624-3632, 2013.

Z. Zhang, V. Ferretti, ?. Güntan, A. Moro, E. A. Steinberg et al., Neuronal ensembles sufficient for recovery sleep and the sedative actions of ?2 adrenergic agonists, Nature Neuroscience, vol.18, issue.4, pp.553-561, 2015.

Y. Ziv, L. D. Burns, E. D. Cocker, E. O. Hamel, K. K. Ghosh et al.,

M. J. Schnitzer, Long-term dynamics of CA1 hippocampal place codes, Nature Neuroscience, vol.16, issue.3, pp.264-266, 2013.

B. Birtoli and D. Ulrich, Firing Mode-Dependent Synaptic Plasticity in Rat Neocortical Pyramidal, Neurons Journal of Neuroscience, vol.24, issue.21, pp.4935-4940, 2004.

F. Brandalise, S. Carta, F. Helmchen, J. Lisman, and U. Gerber, Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells, Nat.Comm, vol.7, p.13480, 2016.

F. Brandalise and U. Gerber, Mossy fiber-evoked subthreshold responses induce timingdependent plasticity at hippocampal CA3 recurrent synapses, PNAS, vol.111, issue.11, pp.4303-4308, 2014.

C. Clopath and W. Gerstner, Voltage and spike timing interact in STDP -a unified model, Frontiers in Synaptic Neuroscience, vol.2, issue.25, p.1, 2010.

C. Clopath, L. Büsing, E. Vasilaki, and W. Gerstner, Connectivity reflects coding: a model of voltage based spike-timing-dependent plasticity with homeostasis, Nat.Neurosci, vol.13, pp.344-352, 2010.

F. Gambino, S. Pages, V. Kehayas, D. Baptista, R. Tatti et al., Single-shock LTD by local dendritic spikes in pyramidal neurons of mouse visual cortex: Dendritic spikes and LTD, The Journal of Physiology, vol.560, issue.1, pp.27-36, 1949.

Y. Humeau and A. Lüthi, Dendritic calcium spikes induce bi-directional synaptic plasticity in the lateral amygdala, Neuropharmacology, vol.52, issue.1, pp.234-243, 2007.

B. M. Kampa, J. J. Letzkus, and G. J. Stuart, Dendritic mechanisms controlling spike-timingdependent synaptic plasticity, Trends in Neurosciences, vol.30, issue.9, p.456, 2007.

B. Kampa and G. Stuart, Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts, The Journal of Neuroscience, vol.26, issue.28, pp.7424-7432, 2006.

B. Kampa, J. Letzkus, and G. Stuart, Requirement of dendritic calcium spikes for induction of spike-timing-dependent synaptic plasticity, J. Physiol. 574, vol.1, pp.283-290, 2006.

J. Letzkus, B. Kampa, and G. Stuart, Learning rules for spike timing-dependent plasticity depend on dendritic synapse location, J. Neurosci, vol.26, pp.10420-10429, 2006.

J. Lisman and N. Spruston, Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing dependent plasticity, Nature Neuroscience, vol.8, issue.7, p.839, 2005.

J. Lisman and N. Spruston, Questions about STDP as a general model of synaptic plasticity, Frontiers in Synaptic Neuroscience, vol.2, issue.140, p.1, 2010.

S. Remy and N. Spruston, Dendritic spikes induce single-burst long-term potentiation, Proceedings of the National Academy of Sciences, vol.104, issue.43, pp.17192-17197, 2007.

J. E. Rubin, R. C. Gerkin, G. Bi, and C. C. Chow, Calcium Time Course as a Signal for Spike-Timing-Dependent Plasticity, J Neurophysiol, vol.93, pp.2600-2613, 2005.

P. J. Sjöström, G. G. Turrigiano, and S. B. Nelson, Rate, timing and cooperativity jointly determine cortical synaptic plasticity, Neuron, vol.32, pp.1149-1164, 2001.

H. Wang, R. Gerkin, D. Nauen, and G. Wang, Coactivation and timing-dependent integration of synaptic potentiation and depression, Nat. Neurosci, vol.8, pp.187-193, 2005.

Z. Xia and D. R. Storm, The role of calmodulin as a signal integrator for synaptic plasticity, Nat.Reviews, vol.6, pp.267-276, 2005.