.. .. Remerciements,

.. .. Sommaire,

I. Herpès, Phylogénie : un virus proche de l'EBV

.. .. Le,

, B. Pathologies tumorales associées à HHV-8

.. .. Le-sarcome-de-kaposi,

L. Maladie-de-castleman-multicentrique and .. .. ,

, lytique de HHV-8 et protéines associées

. Ii and .. .. Lymphocytes-b-et-?-herpèsvirus,

B. , Les ?-Herpèsvirus altèrent la voie de différentiation des lymphocytes B

, 42 2. Les lymphocytes B sous l'influence de l'infection par HHV-8, Les lymphocytes B sous l'influence de l'infection par

C. , Les ?-Herpèsvirus altèrent la prolifération des lymphocytes B

, La prolifération des lymphocytes B infectés est associée à l'expression de la protéine d'HHV-8 LANA, Parallèle entre EBV et HHV-8 pour leurs rôles sur la prolifération des lymphocytes B 48 2

. Iii and .. .. Hhv-8-et-le-système-immunitaire, Les réponses immunes mises en place contre HHV-8

B. Hhv-8-et-Échappement-immunitaire and .. .. ,

, IV. Les lymphocytes T Natural Killer invariants (iNKT)

. .. La-molécule-cd1d, 68 2. Développement, sélection thymique et maturation des cellules iNKT

B. , Maintenance et homéostasie périphérique des cellules iNKT

.. .. Objectifs-de-la-thèse,

.. .. Résultats, 88 I. Altérations des cellules iNKT et des lymphocytes B mémoires dans la Maladie de Castleman Multicentrique associée à l'infection par HHV-8

. .. Hhv-8+, Analyse de la région variable de la chaine lourde de l'IgM exprimée par les lymphocytes B LANA + infectés par HHV-8

. .. Discussion,

.. .. Résumé,

.. .. Bibliographie,

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