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Conception d’un modèle Web sémantique appliqué à la génomique fonctionnelle

Abstract : The general framework of this work is that of the Semantic Web and, more precisely, the application of Semantic Web technologies to functional genomics. The data biologists and physicians access for research purposes are typically available on the Internet. However, this information is also generally distributed over multiple autonomous, heterogeneous sources. We propose a mediator-based approach to integrating biomedical information sources. Our system provides a unique interface for biologists and physicians to access data sources in a centralized and homogeneous way. The use of a mediator is not novel in biomedicine. But existing systems have limitations in terms of conception and evolution, in particular, the need for manual intervention at many levels. To address these issues, we employed semi-automatic methods for creating a mediator-based system. First, we developed an automatic method for acquiring the schemas of the sources to be integrated. Then we used an existing terminological resource, the UMLS, to define a global schema. Finally, we proposed different approaches to mapping local schemas' elements to those of the global schema. These techniques operate at the schema and instance levels and are fully automated. Domain experts can also validate the integration process. The system we created is operational and available on the Internet. The information queried by the system is automatically integrated from multiple sources. Query processing expands users' queries by exploiting a hierarchy of relevant concepts and provides users with the values of the sources elements associated with these concepts. The system can be managed semi-automatically, as its evolution is facilitated by the methods developed for its conception.
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Contributor : Fleur Mougin <>
Submitted on : Tuesday, December 10, 2019 - 12:06:26 PM
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Fleur Mougin. Conception d’un modèle Web sémantique appliqué à la génomique fonctionnelle. Bio-informatique [q-bio.QM]. Université de Rennes 1, 2006. Français. ⟨tel-02402050⟩



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