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Role of melformin and probiotics in the crosstalk between inflammatory bowel disease colorectal cancer and diabetes

Abstract : Background : the co-occurrence of colorectal cancer (CRC), Inflammatory Bowel diseases (IBD) and diabetes mellitus along with inflammation and dysmicrobism has been frequently reported. Several studies shed light on the anti-oncogenic potential of metformin in colorectal carcinogenesis as well as the beneficial effects of probiotics on inflammatory diseases.Aims : this study aimed to demonstrate that metformin in association with probiotics act in a synergic effect in breaking the crosstalk, thus inhibiting CRC progression, improving diabetes and reducing inflammation.Methodology : ninety-six male Balb/c mice, 6-8 weeks old, were divided into 16 control and experimental groups to assess the effect of the different treatments and combinations at the clinical, histological and molecular levels. Pro-inflammatory cytokines IL-6 and TNF- levels were assessed, as well as reactive oxygen and nitrogen species. Moreover, the proliferation index of colocytes was determined by Ki-67 immunohistochemistry.Results : metformin and probiotics showed beneficial outcomes on CRC and diabetes, alone and most importantly in combination. Their effects were exerted by reversing the histopathological alterations and by inhibiting the inflammatory process whereby a downregulation of IL-6 and TNF-α as well as oxidative stress were depicted.Conclusion : the characterization of the effects of probiotics and metformin on CRC and diabetes sheds light on the role of inflammation and microbiota in this crosstalk. Deciphering more the downstream signaling pathways elicited by these compounds will help in developing new effective targeted treatment modalities.
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Submitted on : Thursday, March 4, 2021 - 5:22:22 PM
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Sahar Al Kattar. Role of melformin and probiotics in the crosstalk between inflammatory bowel disease colorectal cancer and diabetes. Human health and pathology. Université de Limoges; Université libanaise, 2020. English. ⟨NNT : 2020LIMO0040⟩. ⟨tel-03159834⟩

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