Abstract: In this paper we show that the optimization of several ranking-based performance measures, such as precision-at-k and average-precision, is intimately related to the solution of quadratic assignment problems. Both the task of test-time prediction of the best ranking and the task of constraint generation in estimators based on structured support vector machines can all be seen as special cases of quadratic assignment problems. Although such problems are in general NP-hard, we identify a polynomially-solvable subclass (for both inference and learning) that still enables the modeling of a substantial number of pairwise rank interactions. We show preliminary results on a public benchmark image annotation data set, which indicates that this model can deliver higher performance over ranking models without pairwise rank dependencies.