Abstract: Cardiovascular diseases remain the first death cause in developed countries. In most cases, exploration of possibly underlying coronary artery pathologies is performed using injected X-ray coronary angiography imaging modality. Current clinical routine in coronary angiography is directly conducted in 2-D from angiograms acquired from several static points of view. However, for diagnosis and treatment purposes, coronary arteries reconstruction is highly suitable. In this report, we propose a novel method to reconstruct coronary arteries from one single rotational X-ray projection sequence. The purpose of this study is to provide physicians with a 3-D model of coronary arteries, e.g. for absolute tridimensional measures for lesion assessment, instead of direct projective measures deducted from the images, which are highly dependent on the point of view. Our method is split in 3 sequential steps: (1) 3-D stereoscopic reconstruction of coronary arteries centerlines, including respiratory motion compensation, (2) coronary arteries 4-D motion computation, and (3) 3-D tomographic reconstruction of coronary arteries, involving compensation for respiratory and cardiac motions. We have successfully tested it on the datasets from a synthetic phantom and16 patients.