inria-00424950, version 2
Model-based Predictions of the Influence of Circadian Clock Genes Knock-Outs on the Cell Cycle
Elisabetta De Maria
1Francois Fages
1Sylvain Soliman 1
N° RR-7064 (2009)
Résumé : The existence of links between the cell division cycle and the circadian clock has been recently discovered. In this research report, we perform a small in silico analysis of how mutations on the clock genes composing the mammalian circadian clock affect the phenotype of the cell cycle. For this purpose, we use a coupled model of the mammalian circadian clock and the mammalian cell cycle where the latter one is entrained by the former one via a common protein kinase WEE1. Our in silico experiments exploit the modeling environment BIOCHAM.
- 1 : CONTRAINTES (INRIA Rocquencourt)
- INRIA
- Domaine : Informatique/Bio-informatique
Sciences du Vivant/Bio-Informatique, Biologie Systémique - Mots-clés : Cell cycle – circadian clock – model coupling – mutations
- Référence interne : RR-7064
- Versions disponibles : v1 (19-10-2009) v2 (20-10-2009)
- inria-00424950, version 2
- http://hal.inria.fr/inria-00424950
- oai:hal.inria.fr:inria-00424950
- Contributeur : Elisabetta De Maria
- Soumis le : Mardi 20 Octobre 2009, 10:44:44
- Dernière modification le : Lundi 23 Novembre 2009, 11:58:04
Documents associés
Exporter