Drones have increasingly been used to assist Humans for rescue and surveillance missions. To do so, their design turns out to be a challenging issue, in particular when their autonomy is expected by sizing of batteries. Thus, solutions are to be sought to engineer a drone rigorously while specifying its main features. This paper introduces a work in progress aiming to bridge the gap between two engineering disciplines that have so far been developed separately: Model Based Systems Engineering (MBSE) and Multidisciplinary Design Analysis and Optimization (MDAO). Coupling of MBSE and MDAO is addressed in terms of language, tools, and methods.